Summary: We investigate the role of gauge and gravitational instantons in the context of the Swampland program. Our focus is on the global symmetry breaking they induce, especially in the presence of fermions. We first recall and make more precise the description of the dilute instanton gas through a 3-form gauge theory. In this language, the familiar suppression of instanton effects by light fermions can be understood as the decoupling of the 3-form. Even if all fermions remain massive, such decoupling may occur on the basis of an explicitly unbroken but anomalous global symmetry in the fermionic sector. This should be forbidden by quantum gravity, which leads us to conjecture a related, cutoff-dependent lower bound on the induced axion potential. Finally, we note that the gravitational counterpart of the above are \(K3\) instantons. These are small fluctuations of Euclidean spacetime with \(K3\) topology, which induce fermionic operators analogous to the ’t Hooft vertex in gauge theories. Although Planck-suppressed, they may be phenomenologically relevant if accompanied by other higher-dimension fermion operators or if the \(K3\) carries appropriate gauge fluxes.