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Marginal longitudinal semiparametric regression via penalized splines. (English) Zbl 1190.62085

Summary: We study the marginal longitudinal nonparametric regression problem and some of its semiparametric extensions. We point out that, while several elaborate proposals for efficient estimation have been proposed, a relative simple and straightforward one, based on penalized splines, has not. After describing our approach, we then explain how Gibbs sampling and the BUGS software can be used to achieve quick and effective implementation. Illustrations are provided for nonparametric regression and additive models.

MSC:

62G08 Nonparametric regression and quantile regression
62H12 Estimation in multivariate analysis
65C60 Computational problems in statistics (MSC2010)

Software:

WinBUGS; nlme; BRugs; R; SemiPar

References:

[1] Brumback, B. A.; Ruppert, D.; Wand, M. P., Comment on paper by Shively, Kohn & Wood, Journal of the American Statistical Association, 94, 794-797 (1999)
[2] Carroll, R. J.; Hall, P.; Apanasovich, T. V.; Lin, X., Histospline method in nonparametric regression models with application to clustered/longitudinal data, Statistica Sinica, 14, 649-674 (2004) · Zbl 1073.62034
[3] Carroll, R. J.; Maity, A.; Mammen, E.; Yu, K., Nonparametric additive regression for repeatedly measured data, Biometrika, 96, 383-398 (2009) · Zbl 1163.62028
[4] Carroll, R. J.; Maity, A.; Mammen, E.; Yu, K., Efficient semiparametric marginal estimation for the partially linear additive model for longitudinal/clustered data, Statistics in Biosciences, 1, 10-31 (2009)
[5] Chen, K.; Jin, Z., Local polynomial regression analysis of clustered data, Biometrika, 92, 59-74 (2005) · Zbl 1068.62043
[6] Coull, B. A.; Ruppert, D.; Wand, M. P., Simple incorporation of interactions into additive models, Biometrics, 57, 539-545 (2001) · Zbl 1209.62352
[7] Crainiceanu, C. M.; Ruppert, D.; Carroll, R. J.; Joshi, A.; Goodner, B., Spatially adaptive Bayesian penalized splines with heteroscedastic errors, Journal of Computational and Graphical Statistics, 16, 265-288 (2007)
[8] Fan, J.; Huang, T.; Li, R., Analysis of longitudinal data with semiparametric estimation of covariance function, Journal of the American Statistical Association, 102, 632-641 (2007) · Zbl 1172.62323
[9] Fan, J.; Wu, Y., Semiparametric estimation of covariance matrixes for longitudinal data, Journal of the American Statistical Association, 103, 1520-1533 (2008) · Zbl 1286.62030
[10] Heagerty, P. J., Marginally specified logistic-normal models for longitudinal binary data, Biometrics, 55, 688-698 (1999) · Zbl 1059.62566
[11] Hu, Z. H.; Wang, N.; Carroll, R. J., Profile-kernel versus backfitting in the partially linear models for longitudinal/clustered data, Biometrika, 91, 251-262 (2004) · Zbl 1210.62086
[12] Kipnis, V.; Subar, A. F.; Midthune, D.; Freedman, L. S.; Ballard-Barbash, R.; Troiano, R.; Bingham, S.; Schoeller, D. A.; Schatzkin, A.; Carroll, R. J., The structure of dietary measurement error: results of the OPEN biomarker study, American Journal of Epidemiology, 158, 14-21 (2003)
[13] Li, Y.; Ruppert, D., On the asymptotics of penalized splines, Biometrika, 95, 415-436 (2008) · Zbl 1437.62540
[14] Lin, X.; Carroll, R. J., Nonparametric function estimation for clustered data when the predictor is measured without/with error, Journal of the American Statistical Association, 95, 520-534 (2000) · Zbl 0995.62043
[15] Lin, X.; Carroll, R. J., Semiparametric regression for clustered data using generalized estimating equations, Journal of the American Statistical Association, 96, 1045-1056 (2001) · Zbl 1072.62566
[16] Lin, X.; Carroll, R. J., Semiparametric estimation in general repeated measures problems, Journal of the Royal Statistical Society, Series B, 68, 68-88 (2006) · Zbl 1141.62026
[17] Lin, X.; Wang, N.; Welsh, A. H.; Carroll, R. J., Equivalent kernels of smoothing splines in nonparametric regression for clustered/longitudinal data, Biometrika, 91, 177-193 (2004) · Zbl 1132.62321
[18] Linton, O. B.; Mammen, E.; Lin, X.; Carroll, R. J., Accounting for correlation in marginal longitudinal nonparametric regression, (Lin, D. Y.; Heagerty, P. J., Proceedings of the Second Seattle Symposium in Biostatistics: Analysis of Correlated Data (2003), Springer: Springer New York), 23-33 · Zbl 1325.62090
[19] Ligges, U., Thomas, A., Spiegelhalter, D., Best, N., Lunn, D., Rice, K., Sturtz, S., 2009. BRugs 0.5-3: Analysis of graphical models using MCMC techniques. R package. http://www.stats.ox.ac.uk/pub/RWin/bin/windows/contrib/2.10; Ligges, U., Thomas, A., Spiegelhalter, D., Best, N., Lunn, D., Rice, K., Sturtz, S., 2009. BRugs 0.5-3: Analysis of graphical models using MCMC techniques. R package. http://www.stats.ox.ac.uk/pub/RWin/bin/windows/contrib/2.10
[20] Lunn, D. J.; Thomas, A.; Best, N.; Spiegelhalter, D., WinBUGS—a Bayesian modelling framework: concepts, structure, and extensibility, Statistics and Computing, 10, 325-337 (2000)
[21] Patterson, H. D.; Thompson, R., Recovery of inter-block information when block sizes are unequal, Biometrika, 58, 545-554 (1971) · Zbl 0228.62046
[22] Pinheiro, J., Bates, D., DebRoy, S., Sarkar, D., The R Core Team, 2009. nlme 3.1: linear and nonlinear mixed effects models. R package. www.R-project.org; Pinheiro, J., Bates, D., DebRoy, S., Sarkar, D., The R Core Team, 2009. nlme 3.1: linear and nonlinear mixed effects models. R package. www.R-project.org
[23] R Development Core Team, 2009. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria, ISBN: 3-900051-07-0. www.R-project.org; R Development Core Team, 2009. R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria, ISBN: 3-900051-07-0. www.R-project.org
[24] Robert, C. P.; Casella, G., Monte Carlo Statistical Methods (2004), Springer-Verlag: Springer-Verlag New York · Zbl 1096.62003
[25] Robinson, G. K., That BLUP is a good thing: the estimation of random effects, Statistical Science, 6, 15-51 (1991) · Zbl 0955.62500
[26] Ruppert, D.; Wand, M. P.; Carroll, R. J., Semiparametric Regression (2003), Cambridge University Press: Cambridge University Press New York · Zbl 1038.62042
[27] Ruppert, D.; Wand, M. P.; Carroll, R. J., Semiparametric regression during 2003-2007, Electronic Journal of Statistics, 3, 1193-1256 (2009) · Zbl 1326.62094
[28] Sun, Y.; Zhang, W.; Tong, H., Estimation of the covariance matrix of random effects in longitudinal studies, The Annals of Statistics, 35, 2795-2814 (2007) · Zbl 1129.62053
[29] Wand, M. P.; Ormerod, J. T., On semiparametric regression with O’Sullivan penalized splines, Australian and New Zealand Journal of Statistics, 50, 179-198 (2008) · Zbl 1146.62030
[30] Wang, N., Marginal nonparametric kernel regression accounting for within-subject correlation, Biometrika, 90, 43-52 (2003) · Zbl 1034.62035
[31] Wang, N.; Carroll, R. J.; Lin, X., Efficient semiparametric marginal estimation for longitudinal/clustered data, Journal of the American Statistical Association, 100, 147-157 (2005) · Zbl 1117.62440
[32] Welham, S. J.; Cullis, B. R.; Kenward, M. G.; Thompson, R., A comparison of mixed model splines for curve fitting, Australian and New Zealand Journal of Statistics, 49, 1-23 (2007) · Zbl 1117.62041
[33] Welsh, A. H.; Lin, X.; Carroll, R. J., Marginal longitudinal nonparametric regression: locality and efficiency of spline and kernel methods, Journal of the American Statistical Association, 97, 482-493 (2002) · Zbl 1073.62529
[34] Zeger, S.; Diggle, P. J., Semiparametric models for longitudinal data with application to CD4 cell numbers in HIV seroconverters, Biometrics, 50, 689-699 (1994) · Zbl 0821.62093
[35] Zhao, Y.; Staudenmayer, J.; Coull, B. A.; Wand, M. P., General design Bayesian generalized linear mixed models, Statistical Science, 21, 35-51 (2006) · Zbl 1129.62063
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