Zinc transporter 4

SLC30A4
Identifiers
Aliases	SLC30A4, ZNT4, znT-4, solute carrier family 30 member 4
External IDs	OMIM: 602095; MGI: 1345282; HomoloGene: 74984; GeneCards: SLC30A4; OMA:SLC30A4 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	45,522,755 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	122,544,583 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; Brodmann area 23; ; middle temporal gyrus; ; oocyte; ; secondary oocyte; ; germinal epithelium; ; endothelial cell; ; external globus pallidus; ; synovial joint; ; gingival epithelium;
	Top expressed in
	jejunum; ; ileum; ; uterus; ; placenta; ; spermatid; ; secondary oocyte; ; genital tubercle; ; Cortex of frontal lobe; ; testicle; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cation transmembrane transporter activity; zinc ion transmembrane transporter activity; protein binding;
Cellular component	cytoplasm; integral component of membrane; endosome; late endosome; membrane; late endosome membrane; lysosomal membrane; lysosome; endosome membrane; plasma membrane;
Biological process	zinc ion homeostasis; zinc ion transport; response to zinc ion; cation transport; ion transport; cation transmembrane transport; transmembrane transport; regulation of sequestering of zinc ion; response to toxic substance; zinc ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	7782
	22785
	ENSG00000104154
	ENSMUSG00000005802
	O14863
	O35149
	NM_013309; NM_001321036
	NM_001290993; NM_011774
	NP_001307965; NP_037441
	NP_001277922; NP_035904
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc transporter 4 is a protein that in humans is encoded by the SLC30A4 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104154 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005802 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SLC30A4 solute carrier family 30 (zinc transporter), member 4".

Huang L, Gitschier J (1997). "A novel gene involved in zinc transport is deficient in the lethal milk mouse". Nat. Genet. 17 (3): 292–7. doi:10.1038/ng1197-292. PMID 9354792. S2CID 8000689.
Murgia C, Vespignani I, Cerase J, et al. (2000). "Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells". Am. J. Physiol. 277 (6 Pt 1): G1231–9. doi:10.1152/ajpgi.1999.277.6.G1231. PMID 10600821. S2CID 31257828.
Küry S, Devilder MC, Avet-Loiseau H, et al. (2001). "Expression pattern, genomic structure and evaluation of the human SLC30A4 gene as a candidate for acrodermatitis enteropathica". Hum. Genet. 109 (2): 178–85. doi:10.1007/s004390100539. PMID 11511923. S2CID 11501283.
Bleck O, Ashton GH, Mallipeddi R, et al. (2002). "Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica". Arch. Dermatol. Res. 293 (8): 392–6. doi:10.1007/s004030100246. PMID 11686514. S2CID 13027648.
Nakano A, Nakano H, Hanada K, et al. (2002). "ZNT4 gene is not responsible for acrodermatitis enteropathica in Japanese families". Hum. Genet. 110 (2): 201–2. doi:10.1007/s00439-001-0661-7. PMID 11935329. S2CID 37006354.
Michalczyk AA, Allen J, Blomeley RC, Ackland ML (2002). "Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells". Biochem. J. 364 (Pt 1): 105–13. doi:10.1042/bj3640105. PMC 1222551. PMID 11988082.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Michalczyk A, Varigos G, Catto-Smith A, et al. (2003). "Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk". Hum. Genet. 113 (3): 202–10. doi:10.1007/s00439-003-0952-2. PMID 12743795. S2CID 36141272.
Henshall SM, Afar DE, Rasiah KK, et al. (2003). "Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer". Oncogene. 22 (38): 6005–12. doi:10.1038/sj.onc.1206797. PMID 12955079.
Beck FW, Prasad AS, Butler CE, et al. (2004). "Differential expression of hZnT-4 in human prostate tissues". Prostate. 58 (4): 374–81. doi:10.1002/pros.10344. PMID 14968438. S2CID 24889031.
Ho LH, Ruffin RE, Murgia C, et al. (2004). "Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation". J. Immunol. 172 (12): 7750–60. doi:10.4049/jimmunol.172.12.7750. PMID 15187159.
Smith JL, Xiong S, Markesbery WR, Lovell MA (2006). "Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain". Neuroscience. 140 (3): 879–88. doi:10.1016/j.neuroscience.2006.02.049. PMID 16580781. S2CID 29807730.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104154 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005802 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLC30A4 solute carrier family 30 (zinc transporter), member 4".

[1]

Zinc transporter 4

See also

References

Further reading