SLC6A14

SLC6A14
Identifiers
Aliases	SLC6A14, BMIQ11, solute carrier family 6 member 14
External IDs	OMIM: 300444; MGI: 1890216; HomoloGene: 38290; GeneCards: SLC6A14; OMA:SLC6A14 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	116,461,458 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	21,608,594 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; nasal epithelium; ; mucosa of paranasal sinus; ; epithelium of bronchus; ; lower lobe of lung; ; parotid gland; ; bronchial epithelial cell; ; amniotic fluid; ; epithelium of nasopharynx; ; olfactory zone of nasal mucosa;
	Top expressed in
	left colon; ; conjunctival fornix; ; left lung lobe; ; right lung; ; vestibular sensory epithelium; ; right lung lobe; ; skin of external ear; ; seminal vesicula; ; olfactory epithelium; ; cornea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	symporter activity; amino acid transmembrane transporter activity; neurotransmitter:sodium symporter activity; transporter activity;
Cellular component	integral component of plasma membrane; membrane; brush border membrane; vesicle; extracellular exosome; integral component of membrane; plasma membrane;
Biological process	neurotransmitter transport; amino acid transport; cellular amino acid metabolic process; response to toxic substance; transmembrane transport; amino acid transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	11254
	56774
	ENSG00000268104
	ENSMUSG00000031089
	Q9UN76
	Q9JMA9
	NM_007231
	NM_020049
	NP_009162
	NP_064433
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded by the SLC6A14 gene.^[5]^[6]

Function

SLC6A14 is a member of the Na⁺- and Cl⁻-dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na⁺- and Cl⁻-dependent manner.[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000268104 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031089 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sloan JL, Mager S (Sep 1999). "Cloning and functional expression of a human Na(+) and Cl(−)-dependent neutral and cationic amino acid transporter B(0+)". J Biol Chem. 274 (34): 23740–5. doi:10.1074/jbc.274.34.23740. PMID 10446133.
^ ^a ^b "Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14".

Ohman M, Oksanen L, Kaprio J, Koskenvuo M, Mustajoki P, Rissanen A, Salmi J, Kontula K, Peltonen L (2000). "Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24". J. Clin. Endocrinol. Metab. 85 (9): 3183–90. doi:10.1210/jcem.85.9.6797. PMID 10999806.
Sloan JL, Grubb BR, Mager S (2003). "Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L39–49. doi:10.1152/ajplung.00164.2002. PMID 12388375.
Suviolahti E, Oksanen LJ, Ohman M, Cantor RM, Ridderstrale M, Tuomi T, Kaprio J, Rissanen A, Mustajoki P, Jousilahti P, Vartiainen E, Silander K, Kilpikari R, Salomaa V, Groop L, Kontula K, Peltonen L, Pajukanta P (2004). "The SLC6A14 gene shows evidence of association with obesity". J. Clin. Invest. 112 (11): 1762–72. doi:10.1172/JCI17491. PMC 281637. PMID 14660752.
Durand E, Boutin P, Meyre D, Charles MA, Clement K, Dina C, Froguel P (2004). "Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians". Diabetes. 53 (9): 2483–6. doi:10.2337/diabetes.53.9.2483. PMID 15331564.
Gupta N, Miyauchi S, Martindale RG, Herdman AV, Podolsky R, Miyake K, Mager S, Prasad PD, Ganapathy ME, Ganapathy V (2005). "Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans". Biochim. Biophys. Acta. 1741 (1–2): 215–23. doi:10.1016/j.bbadis.2005.04.002. PMID 15905073.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000268104 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031089 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10446133-5] Sloan JL, Mager S (Sep 1999). "Cloning and functional expression of a human Na(+) and Cl(−)-dependent neutral and cationic amino acid transporter B(0+)". J Biol Chem. 274 (34): 23740–5. doi:10.1074/jbc.274.34.23740. PMID 10446133.

[entrez-6] "Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14".

[1]

Function

References

Further reading