Drug Repurposing of Bromodomain Inhibitors as Potential Novel Therapeutic Leads for Lymphatic Filariasis Guided by Multispecies Transcriptomics (Q91655025)

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scientific article published on 03 December 2019

Language	Label	Description	Also known as
English	Drug Repurposing of Bromodomain Inhibitors as Potential Novel Therapeutic Leads for Lymphatic Filariasis Guided by Multispecies Transcriptomics	scientific article published on 03 December 2019

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scholarly article

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23 April 2020

Drug Repurposing of Bromodomain Inhibitors as Potential Novel Therapeutic Leads for Lymphatic Filariasis Guided by Multispecies Transcriptomics (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31796568%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

transcriptomics

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based on heuristic

inferred from title

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based on heuristic

inferred from title

1

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23 April 2020

4

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23 April 2020

Julie C Dunning Hotopp

12

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23 April 2020

author name string

Laura E Teigen

2

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23 April 2020

Silvia Libro

3

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23 April 2020

Dustin Olley

5

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23 April 2020

Nikhil Kumar

6

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23 April 2020

Lisa Sadzewicz

7

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23 April 2020

Luke J Tallon

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23 April 2020

Anup Mahurkar

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23 April 2020

Jeremy M Foster

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23 April 2020

Michelle L Michalski

11

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23 April 2020

publication date

3 December 2019

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23 April 2020

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23 April 2020

4

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23 April 2020

6

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23 April 2020

describes a project that uses

object named as

R package WGCNA

WGCNA

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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edgeR

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

Albendazole alone or in combination with microfilaricidal drugs for lymphatic filariasis

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AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis

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Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

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23 February 2021

Multispecies Transcriptomics Data Set of Brugia malayi, Its Endosymbiont Bm, and Aedes aegypti across the B. malayi Life Cycle

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23 February 2021

Targeted enrichment outperforms other enrichment techniques and enables more multi-species RNA-Seq analyses

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6S RNA, a Global Regulator of Transcription.

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BET Proteins as Targets for Anticancer Treatment

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23 February 2021

Global programme to eliminate lymphatic filariasis: progress report, 2016

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23 February 2021

Defining Brugia malayi and Wolbachia symbiosis by stage-specific dual RNA-seq

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23 February 2021

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

1 reference

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23 February 2021

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.

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23 February 2021

The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo

1 reference

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23 February 2021

Bromodomain inhibitors and cancer therapy: From structures to applications

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23 February 2021

Stage-Specific Transcriptome and Proteome Analyses of the Filarial Parasite Onchocerca volvulus and Its Wolbachia Endosymbiont

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23 February 2021

Filarial infection influences mosquito behaviour and fecundity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6890932

23 February 2021

Efficient Enrichment of Bacterial mRNA from Host-Bacteria Total RNA Samples

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23 February 2021

JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer

1 reference

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23 February 2021

The Effects of Ivermectin on Brugia malayi Females In Vitro: A Transcriptomic Approach

1 reference

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23 February 2021

Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications

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23 February 2021

Targeting Filarial Abl-like Kinases: Orally Available, Food and Drug Administration-Approved Tyrosine Kinase Inhibitors Are Microfilaricidal and Macrofilaricidal

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6890932

23 February 2021

Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: "The Worminator".

1 reference

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23 February 2021

Concurrent transcriptional profiling of Dirofilaria immitis and its Wolbachia endosymbiont throughout the nematode life cycle reveals coordinated gene expression

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HTSeq--a Python framework to work with high-throughput sequencing data

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23 February 2021

Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma.

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23 February 2021

Dual RNA-seq of parasite and host reveals gene expression dynamics during filarial worm-mosquito interactions

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6890932

23 February 2021

Intraperitoneal development of the filarial nematode Brugia malayi in the Mongolian jird (Meriones unguiculatus).

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23 February 2021

InterProScan 5: genome-scale protein function classification

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23 February 2021

Genomic, RNAseq, and molecular modeling evidence suggests that the major allergen domain in insects evolved from a homodimeric origin

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23 February 2021

Overcoming the challenges of drug discovery for neglected tropical diseases: the A·WOL experience

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23 February 2021

Integrated transcriptomic and proteomic analysis of the global response of Wolbachia to doxycycline-induced stress.

1 reference

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23 February 2021

Small-molecule inhibition of BRDT for male contraception

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23 February 2021

Efficient subtraction of insect rRNA prior to transcriptome analysis of Wolbachia-Drosophila lateral gene transfer

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23 February 2021

A deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, Brugia malayi

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23 February 2021

The NIH-NIAID Filariasis Research Reagent Resource Center

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23 February 2021

Analysis of two novel midgut-specific promoters driving transgene expression in Anopheles stephensi mosquitoes

1 reference

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23 February 2021

Selective inhibition of BET bromodomains

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6890932

23 February 2021

Lymphatic filariasis and onchocerciasis

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23 February 2021

Using an intravenous catheter to carry out abdominal lavage in the gerbil

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23 February 2021

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

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23 February 2021

The heme biosynthetic pathway of the obligate Wolbachia endosymbiont of Brugia malayi as a potential anti-filarial drug target

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23 February 2021

TopHat: discovering splice junctions with RNA-Seq

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23 February 2021

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

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23 February 2021

WGCNA: an R package for weighted correlation network analysis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6890932

23 February 2021

The Wolbachia endosymbiont of Brugia malayi has an active phosphoglycerate mutase: a candidate target for anti-filarial therapies

1 reference

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23 February 2021

Evolutionary origins of a novel host plant detoxification gene in butterflies

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23 February 2021

Mining predicted essential genes of Brugia malayi for nematode drug targets

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6890932

23 February 2021

Understanding the community impact of lymphatic filariasis: a review of the sociocultural literature.

1 reference

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23 February 2021

RNAmmer: consistent and rapid annotation of ribosomal RNA genes

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23 February 2021

Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity

1 reference

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23 February 2021

Vertebrate yolk complexes and the functional implications of phosvitins and other subdomains in vitellogenins

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23 February 2021

Diethylcarbamazine (DEC)-medicated salt for community-based control of lymphatic filariasis

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23 February 2021

Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures

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23 February 2021

Lymphatic filariasis: Treatment, control and elimination

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6890932

23 February 2021

Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial

1 reference

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23 February 2021

The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode

1 reference

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23 February 2021

Quantification of Wolbachia bacteria in Brugia malayi through the nematode lifecycle.

1 reference

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23 February 2021

Population dynamics of Wolbachia bacterial endosymbionts in Brugia malayi.

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23 February 2021

Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements

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23 February 2021

The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis

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23 February 2021

Assessment of the efficacy of diethylcarbamazine on adult Wuchereria bancrofti in vivo

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23 February 2021

Ultrasonographic assessment of the adulticidal efficacy of repeat high-dose ivermectin in bancroftian filariasis

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23 February 2021

Evolution of the alpha-crystallin/small heat-shock protein family

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23 February 2021

The effect of infection withBrugia pahangiandDirofilaria repenson the egg-production ofAedes aegypti

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23 February 2021

Colorimetric quantitation of filarial viability.

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23 February 2021

Ivermectin as an antiparasitic agent for use in humans

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23 February 2021

Flight muscle ultrastructure of susceptible and refractory mosquitoes parasitized by larvalBrugia pahangi

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23 February 2021

Identifiers

10.1128/MSYSTEMS.00596-19

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31796568%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

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23 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

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23 April 2020

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