Protective hinge in insulin opens to enable its receptor engagement (Q27684937)

object named as

Faramarz Ismail-Beigi

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author name string

Yanwu Yang

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Shu Jin Chan

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Nelson B Phillips

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Jonathan Whittaker

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Linda J Whittaker

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Vijay Pandyarajan

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Zhu-li Wan

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Satya P Yadav

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Julie M Carroll

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Natalie Strokes

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Wieslawa Milewski

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Donald F Steiner

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Virander S Chauhan

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Colin W Ward

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Michael A Weiss

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

19 August 2014

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published in

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volume

111

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issue

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page(s)

E3395-404

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cites work

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29 September 2017

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29 September 2017

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Chemical synthesis of [des(tetrapeptide B27--30), Tyr(NH2)26-B] and [des(pentapeptide B26--30), Phe(NH2)25-B] bovine insulins

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Role of the phenylalanine B24 side chain in directing insulin interaction with its receptor. Importance of main chain conformation

2 June 2018

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Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions

2 June 2018

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2 June 2018

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Structure of Rhombohedral 2 Zinc Insulin Crystals

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Three mutant insulins in man

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Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains

21 January 2018

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Dehydrophenylalanine (DeltaPhe) as a beta breaker: extended structure terminated by a DeltaPhe-induced turn in the pentapeptide Boc-Phe1-Ala2-Ile3-DeltaPhe4-Ala5-OMe

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1412897111

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1412897111

Exploiting the right side of the Ramachandran plot: substitution of glycines by D-alanine can significantly increase protein stability

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1412897111

Probing the mechanism of insulin fibril formation with insulin mutants

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1412897111

Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1412897111

The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1412897111

Chiral mutagenesis of insulin. Contribution of the B20-B23 beta-turn to activity and stability

21 January 2018

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12 December 2020

Disposition of the phenylalanine B25 side chain during insulin-receptor and insulin-insulin interactions

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12 December 2020

The relationship between the connecting peptide of recombined single chain insulin and its biological function

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12 December 2020

Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design

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Alanine scanning mutagenesis of insulin

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1412897111

1 reference

ADS bibcode

2014PNAS..111E3395M

0 references

1 reference

1 reference

PubMed publication ID

25092300

1 reference