Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS (Q27654364)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Qing-xin Hua

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Kun Huang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Shi-Quan Hu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Satoe Nakagawa

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Wenhua Jia

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Shuhua Wang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Jonathan Whittaker

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Panayotis G Katsoyannis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Michael A Weiss

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

language of work or name

English

0 references

publication date

25 March 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

24 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

volume

284

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

page(s)

14586-14596

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS

24 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Crystal Structure ofallo-IleA2-Insulin, an Inactive Chiral Analogue: Implications for the Mechanism of Receptor Binding,

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

The structure of T6 human insulin at 1.0 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

The solution structure of a superpotent b-chain-shortened single-replacement insulin analogue

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

A structural switch in a mutant insulin exposes key residues for receptor binding

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

A model of insulin fibrils derived from the x-ray crystal structure of a monomeric insulin (despentapeptide insulin)

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Solution structure of an engineered insulin monomer at neutral pH

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Structure of a protein in a kinetic trap

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

The structure of 2Zn pig insulin crystals at 1.5 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Receptor binding redefined by a structural switch in a mutant human insulin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Structure of insulin in 4-zinc insulin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Protein folding and misfolding

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

The role of assembly in insulin's biosynthesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Precise mapping of an IGF-I-binding site on the IGF-1R.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Proinsulin is refractory to protein fibrillation: topological protection of a precursor protein from cross-beta assembly

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Structural biology of insulin and IGF1 receptors: implications for drug design

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Protein structure and the spandrels of San Marco: insulin's receptor-binding surface is buttressed by an invariant leucine essential for its stability.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Application of circular dichroism to study RNA folding transitions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

[LeuB24]insulin and [AlaB24]insulin: altered structures and cellular processing of B24-substituted insulin analogs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

A superactive insulin: [B10-aspartic acid]insulin(human).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Cloning of complementary DNAs encoding islet amyloid polypeptide, insulin, and glucagon precursors from a New World rodent, the degu, Octodon degus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Lessons learned from molecular biology of insulin-gene mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Altering the association properties of insulin by amino acid replacement

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Chemical synthesis of [des(tetrapeptide B27--30), Tyr(NH2)26-B] and [des(pentapeptide B26--30), Phe(NH2)25-B] bovine insulins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Receptor-binding region of insulin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Toward understanding insulin fibrillation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Single chain des-(B30) insulin. Intramolecular crosslinking of insulin by trypsin catalyzed transpeptidation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Role of the phenylalanine B24 side chain in directing insulin interaction with its receptor. Importance of main chain conformation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

The insulin A and B chains contain structural information for the formation of the native molecule. Studies with protein disulphide-isomerase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2682906

Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains

2 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

Activities of monomeric insulin analogs at position A8 are uncorrelated with their thermodynamic stabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

Diabetes-associated mutations in insulin identify invariant receptor contacts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

Partially folded intermediates in insulin fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

Putative disulfide-forming pathway of porcine insulin precursor during its refolding in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

A one-pot total synthesis of crambin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

Comparative properties of insulin-like growth factor 1 (IGF-1) and [Gly7D-Ala]IGF-1 prepared by total chemical synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

Probing the mechanism of insulin fibril formation with insulin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900085200

A proposed interaction model of the insulin molecule with its receptor

21 January 2018

1 reference

12 December 2020

Hierarchical protein folding: asymmetric unfolding of an insulin analogue lacking the A7-B7 interchain disulfide bridge

1 reference

12 December 2020

The folding nucleus of the insulin superfamily: a flexible peptide model foreshadows the native state

1 reference

12 December 2020

Engineering stability of the insulin monomer fold with application to structure-activity relationships

1 reference

12 December 2020

Structure and dynamics of a protein assembly. 1H-NMR studies of the 36 kDa R6 insulin hexamer

1 reference

12 December 2020

Receptor binding and biological activity of [SerB24]-insulin, an abnormal mutant insulin

1 reference

12 December 2020

Receptor binding and biologic activity of biosynthetic human insulin and mini-proinsulin produced by recombinant gene technology

1 reference

12 December 2020

Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain

1 reference

12 December 2020

Mutational analysis of invariant valine B12 in insulin: implications for receptor binding

1 reference

12 December 2020

Supernormal insulin: [D-PheB24]-insulin with increased affinity for insulin receptors

1 reference

12 December 2020

Chiral mutagenesis of insulin. Contribution of the B20-B23 beta-turn to activity and stability

1 reference

12 December 2020

The relationship between the connecting peptide of recombined single chain insulin and its biological function

1 reference

12 December 2020

Shortened insulin with enhanced in vitro potency

1 reference

12 December 2020

Importance of aliphatic side-chain structure at positions 2 and 3 of the insulin A chain in insulin-receptor interactions

1 reference

12 December 2020

Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design

1 reference

12 December 2020

A shortened insulin with full in vitro potency

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M900085200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

19321436

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19321436%20AND%20SRC:MED&resulttype=core&format=json