Betanehol

Betanehol
(IUPAC) ime
	2-(karbamoiloksi)- N,N,N-trimetilpropan- 1-aminijum
Klinički podaci
Robne marke	Ureholin
AHFS/Drugs.com	Monografija
MedlinePlus	a682849
Identifikatori
CAS broj	674-38-4
ATC kod	N07AB02
PubChem	2370
DrugBank	APRD00051
ChemSpider	2280
UNII	004F72P8F4
KEGG	C06850
ChEBI	CHEBI:3084
ChEMBL	CHEMBL1482
Hemijski podaci
Formula	C7H17N2O2
Mol. masa	161.221 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1 ; Key: NZUPCNDJBJXXRF-UHFFFAOYSA-O
Sinonimi	2-[(aminokarbonil)oksi]- N,N,N-trimetil- 1-propanaminijum
Farmakoinformacioni podaci
Trudnoća	C(US)
Pravni status
Način primene	Oralno, supkutano

Betanehol je parasimpatomimetički holinski karbamat koji selektivno stimuliše muskarinske receptore. On nema uticaja na nikotinske receptore. Za razliku od acetilholina, betanehol ne hidrolizuje holinesteraza, i iz tog razloga on ima dugo vreme dejstva. Betanehol ne deluje na muskarinski M3 receptor in-vitro^[6].

Betanehol je u prodaji pod imenima Duvoid, Miotonahol, Ureholin i Urokarb.

Upotreba

Betanehol se u nekim slučajevima koristi kao oralni ili supkutani lek za urinarnu retenciju koja je posledica generalne anestezije ili dijabetske neuropatije bešike, ili za tretman gastrointestinalne atonije. Muskarinski receptori bešike i gastrointestinalnog trakta stimulišu kontrakciju bešike, ekspulziju urina, i povišenu gastrointestinalnu motilnost.

Mogućnost primene betanehola u lečenju cerebralne paralize je ispitivana.^[7] Betanehol je jak holinergički agens koji efikasno prolazi kroz krvno-moždanu barijeru i može da ima snažan uticaj na pojačavanje nervne signalizacije i brzine prenosa signala.

Atropin se daje predoperativno za sprečavanje pražnjenja creva/bešike tokom operacije. Betanehol se daje postoperativno da se poništi to dejstvo.^[8]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Benavides-Haro et al. (2003)
↑ Carter WJ (September 2008). „Unexpected benefits of bethanechol in adults with cerebral palsy”. Med. J. Aust. 189 (5): 293. PMID 18759732.
↑ Obied, Hassan (2011). Cholinergic Pharmacology. CSU.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Benavides-Haro et al. (2003)

[pmid18759732-7] Carter WJ (September 2008). „Unexpected benefits of bethanechol in adults with cerebral palsy”. Med. J. Aust. 189 (5): 293. PMID 18759732.

[8] Obied, Hassan (2011). Cholinergic Pharmacology. CSU.

[1]