Route 22 has two main paths. One is a side path that contains several patches of tall grasses and a few Trainers, with an unaccessible Rhyhorn racing track able to be seen to the north. Another serves as a shortcut from Victory Road gate to Santalune City, with ledges preventing the player to go from west to east using this shortcut.
Southwest of the gate is a river with waterfall leading down to two areas. The south one is a puzzle of Strength boulders, while the another contains a large patch of yellow flowers and the entrance to the Chamber of Emptiness.
In the southeast of the route; down a waterfall in the southern, Strength puzzle section; in the southeastern corner (requires Surf and Waterfall; regenerates after 7 days)
In the southeast of the route; down a waterfall in the southern, Strength puzzle section; on the bush west to the southeasternmost Strength boulder hole (requires Surf and Waterfall; hidden)
In the southeast of the route; down a waterfall in the southern, Strength puzzle section; In the northeastern corner accessed after solving the Strength puzzle (requires Surf, Waterfall and Strength)
In the southeast of the route; down a waterfall and then up another one; On a small piece of the land in the northward branch's end (requires Surf and Waterfall)