Optimal control for a nonlinear stochastic PDE model of cancer growth. (English) Zbl 07919197
Summary: We study an optimal control problem for a stochastic model of tumour growth with drug application. This model consists of three stochastic hyperbolic equations describing the evolution of tumour cells. It also includes two stochastic parabolic equations describing the diffusions of nutrient and drug concentrations. Since all systems are subject to many uncertainties, we have added stochastic terms to the deterministic model to consider the random perturbations. Then, we have added control variables to the model according to the medical concepts to control the concentrations of drug and nutrient. In the optimal control problem, we have defined the stochastic and deterministic cost functions and we have proved the problems have unique optimal controls. For deriving the necessary conditions for optimal control variables, the stochastic adjoint equations are derived. We have proved the stochastic model of tumour growth and the stochastic adjoint equations have unique solutions. For proving the theoretical results, we have used a change of variable which changes the stochastic model and adjoint equations (a.s.) to deterministic equations. Then we have employed the techniques used for deterministic ones to prove the existence and uniqueness of optimal control.
MSC:
| 92Cxx | Physiological, cellular and medical topics |
| 92Dxx | Genetics and population dynamics |
| 49S05 | Variational principles of physics |
| 49J55 | Existence of optimal solutions to problems involving randomness |
| 49J20 | Existence theories for optimal control problems involving partial differential equations |
| 49J15 | Existence theories for optimal control problems involving ordinary differential equations |
| 49K45 | Optimality conditions for problems involving randomness |
| 49K20 | Optimality conditions for problems involving partial differential equations |
| 49K15 | Optimality conditions for problems involving ordinary differential equations |
Keywords:
stochastic optimal control; stochastic parabolic-hyperbolic equation; Ekeland variational principle; multicellular tumour spheroid model; free boundary problemReferences:
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