Summary: In this article, the issue of developing an adaptive event-triggered neural control for nonlinear uncertain system with input delay is investigated. The radial basis function neural networks (RBFNNs) are adopted to approximate the uncertain terms, where the time-varying approximation errors are considered into the approximation system. However, the RBFNNs’ weight vector is extended, which may cause the computing burdens. To save network resource, the computing burden caused by the weight vector is handled with the developed adaptive control strategy. Furthermore, in order to compensate the effect of input delay, an auxiliary system is introduced into codesign. With the help of adaptive backstepping technique, an adaptive event-triggered control approach is established. Under the proposed control approach, the effect of input delay can be compensated effectively while the considered system suffered network resource constraint, and all signals in the close-loop system can be guarantee bounded. Finally, two simulation examples are given to verify the proposed control method’s effectiveness.