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Could masks curtail the post-lockdown resurgence of COVID-19 in the US? (English) Zbl 1453.92193

Summary: The community lockdown measures implemented in the United States from late March to late May of 2020 resulted in a significant reduction in the community transmission of the COVID-19 pandemic throughout the country. However, a number of US states are currently experiencing an alarming post-lockdown resurgence of the pandemic, triggering fears for a devastating second pandemic wave. We designed a mathematical model for addressing the key question of whether or not the universal use of face masks can halt such resurgence (and possibly avert a second wave, without having to undergo another cycle of major community lockdown) in the states of Arizona, Florida, New York and the entire US. Model calibration, using cumulative mortality data for the four jurisdictions during their respective pre-lockdown and lockdown periods, show that pre-symptomatic and asymptomatically-infectious individuals are, by far, the main drivers of the COVID-19 pandemic in each of the jurisdictions. The implication of this result is that detecting and isolating individuals with clinical symptoms of the pandemic alone (even if all of them are found) may not be sufficient to effectively curtail the pandemic. To achieve such control, it is crucially-necessary that pre-symptomatic and asymptomatically-infectious individuals are rapidly detected and isolated (and their contacts rapidly traced and tested). Our study highlights the importance of early implementation of the community lockdown measures. In particular, a sizable reduction in the burden of the pandemic would have been recorded in each of the four jurisdictions if the community lockdown measures were implemented a week or two earlier. These reductions are significantly increased if the early implementation of the lockdown measures was complemented with a public face mask use strategy. With all related control measures maintained at their baseline levels, this study shows that the pandemic would have been almost completely suppressed from significantly taking off if the lockdown measures were implemented two weeks earlier, and if a sizable percentage of the residents of the four jurisdictions wore face masks during the respective lockdown periods. The burden of the second wave of the pandemic would have been reduced significantly if the lockdown measures were extended by two weeks. We simulated the pandemic in the four jurisdictions under three levels of lifting of community lockdown, namely mild, moderate and high. For the scenario where the control measures adopted are maintained at their baseline levels during the lockdown period, our simulations show that the states of Arizona and Florida will record devastating second waves of the pandemic by the end of 2020, while the state of New York and the entire US will record milder second waves. If the community lockdown measures were lifted at the mild lifting level (i.e., only limited community contacts and business activities are allowed, in comparison to the levels of these activities allowed during the corresponding lockdown period), only the state of Florida will experience a second wave. It is further shown that the severity of the projected second waves depend on the level of lifting of the community lockdown. For instance, the projected second wave for Arizona and Florida will be more severe than their respective first waves. It is further shown that, for high level of lifting of community lockdown measures, the increased use of face masks after the lockdown period greatly reduces the burden of the pandemic in each jurisdiction. In particular, for this high lockdown lifting scenario, none of the four jurisdictions will experience a second wave if half of their residents wear face masks consistently after their respective lockdown period. A diagnostic testing strategy that increases the maximum detection rate of asymptomatic infected individuals (followed by contact tracing and self-isolation of the detected cases) greatly reduces the burden of the pandemic in all four jurisdictions, particularly if also combined with a universal face mask use strategy. Finally, it is shown that the universal use of face masks in public, with at least moderate level of compliance, could halt the post-lockdown resurgence of COVID-19, in addition to averting the potential for (and severity of) a second wave of the pandemic in each of the four jurisdictions.

MSC:

92C60 Medical epidemiology

References:

[1] World Health Organization, Emergencies, preparedness, response. Pneumonia of unknown origin - China, Disease Outbreak News, 5 January (2020), Online Version, (Accessed 5 March 2020)
[2] Li, Q.; Guan, X.; Wu, P.; Wang, X.; Zhou, L.; Tong, Y.; Ren, R.; Leung, K. S.; Lau, E. H.; Wong, J. Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia, New Engl. J. Med. (2020)
[3] Ngonghala, C. N.; Iboi, E.; Eikenberry, S.; Scotch, M.; MacIntyre, C. R.; Bonds, M. H.; Gumel, A. B., Mathematical assessment of the impact of non-pharmaceutical interventions on curtailing the 2019 novel Coronavirus, Math. Biosci., Article 108364 pp. (2020) · Zbl 1448.92135
[4] World Health Organization, C. N., Coronavirus disease (COVID-2019) situation reports, WHO (2020), Online Version, (Accessed 26 April 2020)
[5] Dong, E.; Du, H.; Gardner, L., An interactive web-based dashboard to track COVID-19 in real time, Lancet Infect. Dis., 20, 5, 533-534 (2020)
[6] Worldometer, E., COVID-19 coronavirus pandemic: reported cases and deaths by country, territory, or conveyance, Worldometer (2020), Online Version, (Accessed 2 May 2020)
[7] Czachor, E., Houston ICUs at 97 percent capacity as texas coronavirus cases break records, News Week (2020), Online Version, (Accessed 25 June 2020)
[8] Leonhardt, D., Arizona is #1, Bahrain is #4 and what else you need to know today, N.Y. Times (2020), Online Version, (Accessed 9 July 2020)
[9] van Doremalen, N.; Bushmaker, T.; Morris, D. H.; Holbrook, M. G.; Gamble, A.; Williamson, B. N.; Tamin, A.; Harcourt, J. L.; Thornburg, N. J.; Gerber, S. I., Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1, New Engl. J. Med. (2020)
[10] World Health Organization, N., Coronavirus disease 2019 (COVID-19): situation report, 46, WHO (2020)
[11] Liu, Y.; Yan, L.-M.; Wan, L.; Xiang, T.-X.; Le, A.; Liu, J.-M.; Peiris, M.; Poon, L. L.; Zhang, W., Viral dynamics in mild and severe cases of COVID-19, Lancet Infect. Dis. (2020)
[12] Silverstein, W. K.; Stroud, L.; Cleghorn, G. E.; Leis, J. A., First imported case of 2019 novel coronavirus in Canada, presenting as mild pneumonia, Lancet, 395, 10225, 734 (2020)
[13] Yang, X.; Yu, Y.; Xu, J.; Shu, H.; Liu, H.; Wu, Y.; Zhang, L.; Yu, Z.; Fang, M.; Yu, T., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study, Lancet Respir. Med. (2020)
[14] Xu, X.-W.; Wu, X.-X.; Jiang, X.-G.; Xu, K.-J.; Ying, L.-J.; Ma, C.-L.; Li, S.-B.; Wang, H.-Y.; Zhang, S.; Gao, H.-N., Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series, British Med. J., 368 (2020)
[15] Young, B. E.; Ong, S. W.X.; Kalimuddin, S.; Low, J. G.; Tan, S. Y.; Loh, J.; Ng, O.-T.; Marimuthu, K.; Ang, L. W.; Mak, T. M., Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore, JAMA (2020)
[16] Wu, Z.; McGoogan, J. M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention, JAMA (2020)
[17] Rajesh, T. G.; John, B. L.; del Rio, C., Mild or moderate Covid-19, New Engl. J. Med. (Clinical Practice) (2020), Online Version
[18] He, X.; Lau, E. H.Y.; Wu, P.; Deng, X.; Wang, J.; Hao, X.; Lau, Y. C.; Wong, J. Y.; Guan, Y.; Tan, X.; Mo, X.; Chen, Y.; Liao, B.; Chen, W.; Hu, F.; Zhang, Q.; Zhong, M.; Wu, Y.; Zhao, L.; Zhang, F.; Cowling, B. J.; Li, F.; Leung, G. M., Temporal dynamics in viral shedding and transmissibility of COVID-19, Nature Med. (2020), Online Version
[19] Zou, L.; Ruan, F.; Huang, M.; Liang, L.; Huang, H.; Hong, Z.; Yu, J.; Kang, M.; Song, Y.; Xia, J., SARS-CoV-2 viral load in upper respiratory specimens of infected patients, New Engl. J. Med., 382, 12, 1177-1179 (2020)
[20] Nishiura, H.; Kobayashi, T.; Miyama, T.; Suzuki, A.; Jung, S.; Hayashi, K.; Kinoshita, R.; Yang, Y.; Yuan, B.; Akhmetzhanov, A. R., Estimation of the asymptomatic ratio of novel coronavirus infections (COVID-19), medRxiv (2020)
[21] Mizumoto, K.; Kagaya, K.; Zarebski, A.; Chowell, G., Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the diamond princess cruise ship, Yokohama, Japan, 2020, Eurosurveillance, 25, 10, Article 2000180 pp. (2020)
[22] Tindale, L. C.; Stockdale, J. E.; Coombe, M.; Garlock, E. S.; Lau, W. Y.V.; Saraswat, M.; Zhang, L.; Chen, D.; Wallinga, J.; Colijn, C., Evidence for transmission of COVID-19 prior to symptom onset, eLife, 9, Article e57149 pp. (2020)
[23] Moghadas, S. M.; Fitzpatrick, M. C.; Sah, P.; Pandey, A.; Shoukat, A.; Singer, B. H.; Galvani, A. P., The implications of silent transmission for the control of COVID-19 outbreaks, Proc. Natl. Acad. Sci. (2020), Online Version
[24] Callaway, E., Scores of coronavirus vaccines are in competition — how will scientists choose the best?, Nature Res. J. (2020), Online Version, (Accessed 30 April 2020)
[25] Kirkpatrick, D., In race for a Coronavirus vaccine, an oxford group leaps ahead, N.Y. Times (2020), Online Version, (Accessed 2 May 2020)
[26] Knvul, S.; Katie, T., More coronavirus vaccines and treatments move toward human trials, N.Y. Times (2020), Online Version, (Accessed 2 May 2020)
[27] Iboi, E. A.; Ngonghala, C. N.; Gumel, A. B., Will an imperfect vaccine curtail the COVID-19 pandemic in the US?, Infect. Dis. Model., 5, 510-524 (2020)
[28] Radonovich, L. J.; Simberkoff, M. S.; Bessesen, M. T.; Brown, A. C.; Cummings, D. A.; Gaydos, C. A.; Los, J. G.; Krosche, A. E.; Gibert, C. L.; Gorse, G. J., N95 respirators vs medical masks for preventing influenza among health care personnel: a randomized clinical trial, JAMA, 322, 9, 824-833 (2019)
[29] Offeddu, V.; Yung, C. F.; Low, M. S.F.; Tam, C. C., Effectiveness of masks and respirators against respiratory infections in healthcare workers: a systematic review and meta-analysis, Clin. Infect. Dis., 65, 11, 1934-1942 (2017)
[30] Feng, S.; Shen, C.; Xia, N.; Song, W.; Fan, M.; Cowling, B. J., Rational use of face masks in the COVID-19 pandemic, Lancet Respir. Med. (2020)
[31] Cohen, J., Not wearing masks to protect against coronavirus is a ‘big mistake’, top chinese scientist says’, Sci. Mag., 27 (2020)
[32] John Hopkins University, J., Daily State-by-State Testing Trends (2020), John Hopkins University Coronavirus resource center, Online Version, (Accessed 9 July 2020)
[33] Mervosh, S.; Lee, J. C.; Gamio, L.; Popovich, N., See how all 50 states are reopening, N.Y. Times (2020), Online Version, (Accessed 25 June 2020)
[34] White House Coronavirus Task Force, S., Opening up America again, White House (2020), Online Version, (Accessed 2 July 2020)
[35] Collins, K.; Leatherby, L., Most states that are reopening fail to meet White House guidelines, N.Y. Times (2020), Online Version, (Accessed 2 July 2020)
[36] Bendix, A., Nearly half of states reopened before meeting the White House safety criteria. Their new surges were entirely predictable, Business Insider (Science News) (2020), Online Version, (Accessed 2 July 2020)
[37] Bote, J.; Hauck, G., At least 21 states pause reopening or take new steps to limit the spread of COVID-19, USA Today (2020), Online Version, (Accessed 3 July 2020)
[38] Kelleher, S. R., These U.S. cities and states have hit the pause button on reopening, Forbes (2020), Online Version, (Accessed 3 July 2020)
[39] Allen Kim, S. A.; Froio, J., These are the states requiring people to wear masks when out in public, CNN (2020), Online Version, (Accessed 3 July 2020)
[40] Mendelson, L., Facing your face mask duties – a list of statewide orders, as of July 2, 2020, Littler (2020), Online Version, (Accessed 3 July 2020)
[41] Eikenberry, S. E.; Muncuso, M.; Iboi, E.; Phan, T.; Kostelich, E.; Kuang, Y.; Gumel, A. B., To mask or not to mask: Modeling the potential for face mask use by the general public to curtail the COVID-19 pandemic, Infect. Dis. Model., 5, 293-308 (2020)
[42] Stein, R.; Wroth, C.; Hurt, A., US Coronavirus testing still falls short. How’s your state doing?, Health News Natl. Public Radio (2020), Online Version, (Accessed 11 May 2020)
[43] World Health Organization, R., Coronavirus disease (COVID-2019) situation dashboard, WHO (2020), Online Version, (Accessed 2 May 2020)
[44] World Health Organization, R., Novel coronavirus (2019-nCoV) situation reports, WHO (2020), Online Version, (Accessed 2 May 2020)
[45] Dong, E.; Du, H.; Gardner, L., Coronavirus COVID-19 global cases by Johns Hopkins CSSE, Lancet Infect. Dis. (2020), Online Version
[46] Lau, H.; Khosrawipour, T.; Kocbach, P.; Ichii, H.; Bania, J.; Khosrawipour, V., Evaluating the massive underreporting and undertesting of COVID-19 cases in multiple global epicenters, Pulmonology (2020)
[47] Sun, L. H.; Achenbach, J., CDC Chief says coronavirus cases may be 10 times higher than reported, Washington Post (Health) (2020), Online Version, (Accessed 3 July 2020)
[48] King, A. A.; Domenech de Cellès, M.; Magpantay, F. M.; Rohani, P., Avoidable errors in the modelling of outbreaks of emerging pathogens, with special reference to Ebola, Proc. R. Soc. B, 282, 1806, Article 20150347 pp. (2015)
[49] Arino, J.; Brauer, F.; Van Den Driessche, P.; Watmough, J.; Wu, J., A final size relation for epidemic models, Math. Biosci. Eng., 4, 2, 159 (2007) · Zbl 1123.92030
[50] Brauer, F., A final size relation for epidemic models of vector-transmitted diseases, Infect. Dis. Model., 2, 1, 12-20 (2017)
[51] Brauer, F., The final size of a serious epidemic, Bull Math. Biol., 81, 3, 869-877 (2019) · Zbl 1415.92172
[52] Diekmann, O.; Heesterbeek, J. A.P.; Metz, J. A., On the definition and the computation of the basic reproduction ratio \(R_0\) in models for infectious diseases in heterogeneous populations, J. Math. Biol., 28, 4, 365-382 (1990) · Zbl 0726.92018
[53] van den Driessche, P.; Watmough, J., Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission, Math. Biosci., 180, 1-2, 29-48 (2002) · Zbl 1015.92036
[54] Nishiura, H.; Chowell, G., The effective reproduction number as a prelude to statistical estimation of time-dependent epidemic trends, (Mathematical and Statistical Estimation Approaches in Epidemiology (2009), Springer), 103-121 · Zbl 1345.92151
[55] Baker, M. G.; Kvalsvig, A.; Verrall, A. J.; Telfar-Barnard, L.; Wilson, N., New Zealand’s elimination strategy for the COVID-19 pandemic and what is required to make it work, New Zealand Med. J. (Online), 133, 1512, 10-14 (2020)
[56] Tian, H.; Liu, Y.; Li, Y.; Wu, C.-H.; Chen, B.; Kraemer, M. U.G.; Li, B.; Cai, J.; Xu, B.; Yang, Q.; Wang, B.; Yang, P.; Cui, Y.; Song, Y.; Zheng, P.; Wang, Q.; Bjornstad, O. N.; Yang, R.; Grenfell, B.; Pybus, O.; Dye, C., The impact of transmission control measures during the first 50 days of the COVID-19 epidemic in China, medRxiv (2020), Online Version
[57] Cyranoski, D., What China’s coronavirus response can teach the rest of the world: researchers are studying the effects of China’s lockdowns to glean insights about controlling the viral pandemic, Nature, 579, 479-480 (2020), Online Version
[58] Parker, R. W., Lessons from New Zealand’s COVID-19 success, Regulat. Rev. (2020), Online Version, (Accessed 10 July 2020)
[59] Brockett, M., This country says it’s on course to wipe out Covid-19, Bloomberg (2020), Online Version, (Accessed 10 July 2020)
[60] Hjelmgaard, K.; Lyman, E. J.; Shesgreen, D., This is what China did to beat coronavirus. Experts say America couldn’t handle it, USA Today (2020), Online Version, (Accessed 10 July 2020)
[61] New York Times, K., What are the phases of New York’s reopening plan?, N.Y. Times (2020), Online Version, (Accessed 4 July 2020)
[62] FOX10 staff, K., List: Arizona cities with face mask requirements, FOX10 Phoenix (2020), Online Version, (Accessed 12 July 2020)
[63] Ogles, B., Beyond the veil: What mask requirements are in place in florida?, FLAPOL (2020), Online Version, (Accessed 12 July 2020)
[64] Cuomo, A., Governor Cuomo announces lowest COVID-19 deaths and hospitalizations in new york since the pandemic began, Information on Coronavirus (2020), Online Version, (Accessed 2 July 2020)
[65] Croft, J.; Maxouris, C.; Wood, D., Record increases of new Covid-19 cases in 3 US states with the most population, CNN (2020), Online Version
[66] Centers for Disease Control and Prevention, J., Considerations for schools, CDC (2020), Online Version, (Accessed 9 July 2020)
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