Summary: K. K. G. Lan and D. L. DeMets [Biometrika 70, 659–663 (1983; Zbl 0543.62059)] proposed the alpha spending function for group sequential trials to permit the use of unspecified frequencies and timings of interim analyses in the trial design. Regarding a trial with censored time to endpoint, K. K. G. Lan and D. L. DeMets [“Group sequential procedures: Calendar versus information time”, Stat. Med. 8, No. 10, 1191–1198 (1989; doi:10.1002/sim.4780081003) later defined information time at an interim analysis in a maximum duration trial. To compare two survival curves utilizing such a design, information times for group sequential logrank and Wilcoxon-type statistics have been developed by assuming that the survival time follows an exponential distribution or a Weibull distribution without considering the censoring distribution. To better address the practical concerns inherent in clinical trials with survival endpoints, we present a new approach to adequately design a group sequential trial using the D. P. Harrington and T. R. Fleming test [Biometrika 69, 553–565 (1982; Zbl 0532.62026)] based on our proposed information fractions by assuming the censoring distribution depends on the patient’s accrual time according to various entry distributions and by extending the underlying survival distribution to the generalized gamma distribution. We also determine associated sample sizes, expected number of events and expected stopping time. Two phase III trials of non-small-cell lung cancer originally designed using fixed-sample tests are utilized to illustrate the potential advantages of using a group sequential design with the proposed approach. This enhanced method facilitates the design and analysis of group sequential clinical trials studying survival endpoints by increasing implemental flexibility.