×

On a curvature flow model for embryonic epidermal wound healing. (English) Zbl 1429.53075

Summary: The paper is a mathematical investigation of a curvature flow model for embryonic epidermal wound healing proposed by A. Ravasio et al. [“Gap geometry dictates epithelial closure efficiency”, Nature Commun. 6, Article No. 7683, 13 p. (2015)]. Under the flow we show that a closed, initially convex or close-to-convex curve shrinks to a round point in finite time. We also study the singularity, showing that the singularity profile after continuous rescaling is that of a circle. One of the key new results we require is a maximal time estimate, which is also of independent interest.

MSC:

53C42 Differential geometry of immersions (minimal, prescribed curvature, tight, etc.)
53E99 Geometric evolution equations
58J35 Heat and other parabolic equation methods for PDEs on manifolds
35Q92 PDEs in connection with biology, chemistry and other natural sciences
92C45 Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.)

References:

[1] Abresch, Uwe; Langer, Joel, The normalized curve shortening flow and homothetic solutions, J. Differential Geom., 23, 2, 175-196 (1986) · Zbl 0592.53002
[2] Almeida, Luís; Bagnerini, Patrizia; Habbal, Abderrahmane, Modeling actin cable contraction, Comput. Math. Appl., 64, 3, 310-321 (2012) · Zbl 1252.92027
[3] Bernard, Yann; Wheeler, Glen; Wheeler, Valentina-Mira, Concentration-compactness and finite-time singularities for Chen’s flow, J. Math. Sci. Univ. Tokyo, 26, 55-139 (2019) · Zbl 1425.53079
[4] Breuning, Patrick, Immersions with bounded second fundamental form, J. Geom. Anal., 25, 2, 1344-1386 (2015) · Zbl 1318.53060
[5] Chou, Kai-Seng; Zhu, Xi-Ping, Anisotropic flows for convex plane curves, Duke Math. J., 97, 3, 579-619 (1999) · Zbl 0946.53033
[6] Chou, Kai-Seng; Zhu, Xi-Ping, A convexity theorem for a class of anisotropic flows of plane curves, Indiana Univ. Math. J., 139-154 (1999) · Zbl 0979.53074
[7] Chou, Kai-Seng; Zhu, Xi-Ping, The curve shortening problem (2001), CRC Press · Zbl 1061.53045
[8] Colwell, Amy; Longaker, Michael; Lorenz, Hermann, Fetal wound healing, Front. Biosci.: J. Virtual Libr., 8, s1240-s1248 (2003)
[9] Dale, Paul; Sherratt, Jonathan; Maini, Philip, A mathematical model for collagen fibre formation during foetal and adult dermal wound healing, Proc. R. Soc. Lond. Ser. B: Biol. Sci., 263, 1370, 653-660 (1996)
[10] Dallaston, Michael C.; McCue, Scott W., A curve shortening flow rule for closed embedded plane curves with a prescribed rate of change in enclosed area, Proc. R. Soc. A, 472, 2185, 20150629 (2016) · Zbl 1371.53062
[11] Deckelnick, Klaus, Weak solutions of the curve shortening flow, Calc. Var. Partial Differential Equations, 5, 6, 489-510 (1997) · Zbl 0990.35076
[12] Gage, Michael, Curve shortening makes convex curves circular, Invent. Math., 76, 2, 357-364 (1984) · Zbl 0542.53004
[13] Gage, Michael; Hamilton, Richard, The heat equation shrinking convex plane curves, J. Differential Geom., 23, 1, 69-96 (1986) · Zbl 0621.53001
[14] Galaktionov, Victor A., Geometric Sturmian theory of nonlinear parabolic equations and applications (2004), CRC Press · Zbl 1075.35017
[15] Grayson, Matthew, The heat equation shrinks embedded plane curves to round points, J. Differential Geom., 26, 285-314 (1987) · Zbl 0667.53001
[16] Gurtner, Geoffrey; Callaghan, Matthew; Longaker, Michael, Progress and potential for regenerative medicine, Annu. Rev. Med., 58, 299-312 (2007)
[17] Gurtner, Geoffrey; Werner, Sabine; Barrandon, Yann; Longaker, Michael, Wound repair and regeneration, Nature, 453, 7193, 314-321 (2008)
[18] He, Shuhui, Curvature flows in wound healing (2019), University of Wollongong: University of Wollongong Australia, (PhD thesis) · Zbl 1429.53075
[19] Huisken, Gerhard, Flow by mean curvature of convex surfaces into spheres, J. Differential Geom., 20, 1, 237-266 (1984) · Zbl 0556.53001
[20] Huisken, Gerhard, Asymptotic behavior for singularities of the mean curvature flow, J. Differential Geom., 31, 1, 285-299 (1990) · Zbl 0694.53005
[21] Kuwert, Ernst; Schätzle, Reiner, Gradient flow for the willmore functional, Comm. Anal. Geom., 10, 2, 307-340 (2002) · Zbl 1029.53082
[22] McCoy, James; Parkins, Scott; Wheeler, Glen, The geometric triharmonic heat flow of immersed surfaces near spheres, Nonlinear Anal., 161, 44-86 (2017) · Zbl 1477.53094
[23] McCoy, James; Wheeler, Glen, Finite time singularities for the locally constrained willmore flow of surfaces, Comm. Anal. Geom., 24, 4, 843-886 (2016) · Zbl 1365.53007
[24] McCoy, James; Wheeler, Glen; Williams, Graham, Lifespan theorem for constrained surface diffusion flows, Math. Z., 269, 1, 147-178 (2011) · Zbl 1230.53062
[25] McCoy, James; Wheeler, Glen; Wu, Yuhan, A sixth order flow of plane curves with boundary conditions (2017), arXiv preprint arXiv:1710.09546 · Zbl 1417.53003
[26] McDougall, Steven; Dallon, John; Sherratt, Jonathan; Maini, Philip, Fibroblast migration and collagen deposition during dermal wound healing: Mathematical modelling and clinical implications, Phil. Trans. R. Soc. A, 364, 1843, 1385-1405 (2006)
[27] Olsen, Lene; Sherratt, Jonathan; Maini, Philip; Arnold, Frederick, A mathematical model for the capillary endothelial cell-extracellular matrix interactions in wound-healing angiogenesis, Math. Med. Biol., 14, 4, 261-281 (1997) · Zbl 0891.92016
[28] Parkins, Scott; Wheeler, Glen, The polyharmonic heat flow of closed plane curves, J. Math. Anal. Appl., 439, 2, 608-633 (2016) · Zbl 1381.58010
[29] Parkins, Scott; Wheeler, Glen, The anisotropic polyharmonic curve flow for closed plane curves, Calc. Var. Partial Differential Equations, 58, 2, 70 (2017) · Zbl 1410.53068
[30] Ravasio, Andrea; Cheddadi, Ibrahim; Chen, Tianchi; Pereira, Telmo; Ong, Hui Ting; Bertocchi, Cristina; Brugues, Agusti; Jacinto, Antonio; Kabla, Alexandre J.; Toyama, Yusuke, Gap geometry dictates epithelial closure efficiency, Nat. Commun., 6 (2015)
[31] Shomberg, Joseph L., Exponential decay results for semilinear parabolic PDE with \(C^0\) potentials: A “mean value” approach, Differ. Equ. Dyn. Syst., 1-16 (2014)
[32] Struwe, Michael, On the evolution of harmonic mappings of Riemannian surfaces, Comment. Math. Helv., 60, 1, 558-581 (1985) · Zbl 0595.58013
[33] Tsai, Dong-Ho; Wang, Xiao-Liu, The evolution of nonlocal curvature flow arising in a Hele-Shaw problem, SIAM J. Math. Anal., 50, 1, 1396-1431 (2018) · Zbl 1392.35334
[34] Wheeler, Glen, Lifespan theorem for simple constrained surface diffusion flows, J. Math. Anal. Appl., 375, 2, 685-698 (2011) · Zbl 1207.35077
[35] Wheeler, Glen, Surface diffusion flow near spheres, Calc. Var. Partial Differential Equations, 44, 1, 131-151 (2012) · Zbl 1238.53043
[36] Wheeler, Glen, On the curve diffusion flow of closed plane curves, Ann. Mat. Pura Appl., 192, 5, 931-950 (2013) · Zbl 1277.53068
[37] Wheeler, Glen, Global analysis of the generalised Helfrich flow of closed curves immersed in \(R^n\), Trans. Amer. Math. Soc., 367, 4, 2263-2300 (2015) · Zbl 1321.53085
[38] Wheeler, Glen; Wheeler, Valentina-Mira, Curve diffusion and straightening flows on parallel lines (2017), arXiv preprint arXiv:1703.10711 · Zbl 1383.74017
This reference list is based on information provided by the publisher or from digital mathematics libraries. Its items are heuristically matched to zbMATH identifiers and may contain data conversion errors. In some cases that data have been complemented/enhanced by data from zbMATH Open. This attempts to reflect the references listed in the original paper as accurately as possible without claiming completeness or a perfect matching.