Authors’ abstract: We investigate the ground states of the one-dimensional nonlinear Schrödinger equation with a defect located at a fixed point. The nonlinearity is focusing and consists of a subcritical power. The notion of ground state can be defined in several (often non-equivalent) ways. We define a ground state as a minimizer of the energy functional among the functions endowed with the same mass. This is the physically meaningful definition in the main fields of application of NLS. In this context we prove an abstract theorem that revisits the concentration-compactness method and which is suitable to treat NLS with inhomogeneities. Then we apply it to three models, describing three different kinds of defect: delta potential, delta prime interaction, and dipole. In the three cases we explicitly compute ground states and we show their orbital stability.