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Blood flow through a stenosed catheterized artery: effects of hematocrit and stenosis shape. (English) Zbl 1189.76809

Summary: The problem of blood flow through a narrow catheterized artery with an axially nonsymmetrical stenosis has been investigated. Blood is represented by a two-phase macroscopic model, i.e., a suspension of erythrocytes (red cells) in plasma (Newtonian fluid). The coupled differential equations for both fluid (plasma) and particle (erythrocyte) phases have been solved and the expression for the flow characteristics, namely, the flow rate, the impedance (resistance to flow), the wall shear stress and the shear stress at the stenosis throat have been derived. It is found that the impedance increases with the catheter size, the hematocrit and the stenosis size (height and length) but decreases with the shape parameter. A significant increase in the magnitude of the impedance and the wall shear stress occurs even for a small increase in the catheter size. The flow resistance increases and the shear stress at the stenosis throat decreases with the increasing catheter size and assume an asymptotic value at about the catheter size half of the artery size.

MSC:

76Z05 Physiological flows
92C35 Physiological flow
Full Text: DOI

References:

[1] Kanai, H.; Lizuka, M.; Sakamotos, K., One of the problem in the measurement of blood pressure by catheterization: Wave reflection at the tip of catheter, Med. Biol. Engr., 28, 483-496 (1970)
[2] Gunj, P.; Abben, R.; Friedman, P. L.; Granic, J. D.; Barry, W. H.; Levin, D. C., Usefulness of transstenotic coronary pressure gradient measurements during diagnostic catheterization, Am. J. Cardiol., 55, 910-914 (1985)
[3] Anderson, H. V.; Roubin, G. S.; Leimgruber, P. P.; Cox, W. R.; Douglas, J. S.; King, S. B.; Gruentzig, A. R., Measurement of transstenotic pressure gradient during percutaneous tranluminal coronary angioplasty, Circulation, 73, 1223-1230 (1986)
[4] Wilson, R. F.; Johnson, M. R.; Marcus, M. L.; Aylward, P. E.G.; Skorton, D.; Collins, S.; White, C. W., The effect of coronary angioplasty on coronary flow reserve, Circulation, 77, 873-885 (1988)
[5] Leimgruber, P. P.; Roubin, G. S.; Anderson, H. V.; Bredlau, C. E.; Whiteworth, H. B.; Douglas, J. S.; King, S. B.; Gruentzig, A. R., Influence of intimal dissection on restenosis after successful coronary angioplasty, Circulation, 72, 530-535 (1985)
[6] Back, L. H., Estimated mean flow resistance increases during coronary artery catheterization, J. Biomech., 27, 169-175 (1994)
[7] Back, L. H.; Kwack, E. Y.; Back, M. R., Flow rate-pressure drop relation in coronary angioplasty: Catheter obstruction effect, J. Biomed. Eng., 118, 83-89 (1996)
[8] Sarkar, A.; Jayaraman, G., Corretion to flow rate-pressure drop in coronary angioplasty: Steady streaming effect, J. Biomech., 31, 781-791 (1998)
[9] Dash, R. K.; Jayaraman, G.; Mehta, K. N., Flow in a catheterized curved artery with stenosis, J. Biomech., 49-61 (1999)
[10] Sankar, D. S.; Hemlatha, K., Pulsatile flow of Herschel-Bulkley fluid through catheterized arteries — a mathematical model, Appl. Math. Modelling, 31, 1497-1517 (2007) · Zbl 1130.76091
[11] Srivastava, V. P.; Srivastava, Rashmi, Particulate suspension blood flow through a narrow catheterized artery, Comput. Math. Appl., 58, 227-238 (2009) · Zbl 1189.76810
[12] Srivastava, V. P., Two-phase model of blood flow through stenosed tubes in the presence of a peripheral layer: Applications, J. Biomech., 29, 1377-1382 (1996)
[13] Srivastava, L. M.; Srivastava, V. P., On two-phase model of pulsatile blood flow with entrance effects, Biorheology, 20, 761-777 (1983)
[14] Drew, D. A., Two-phase flow: Constitutive equations for lift and Brownian motion and some basic flows, Arch. Ration Mech. Anal., 62, 149-158 (1976) · Zbl 0382.76083
[15] Drew, D. A., Stability of Stokes layer of a dusty gas, Phys. Fluids, 19, 2081-2084 (1979) · Zbl 0434.76062
[16] Srivastava, L. M.; Edemeka, U. E.; Srivastava, V. P., Particulate suspension model for blood flow under external body acceleration, Int. J. Biomed. Comput., 37, 113-129 (1994)
[17] Tam, C. K.W., The drag on a cloud of Spherical particles in low Reynolds number flows, J. Fluid Mech., 38, 537-546 (1969) · Zbl 0184.52701
[18] Charm, S. E.; Kurland, G. S., Blood Flow and Microcirculation (1974), John Wiley: John Wiley New York
[19] Young, D. F., Effects of a time-dependent stenosis on flow through a tube, J. Eng. Ind., 90, 248-254 (1968)
[20] Srivastava, V. P., Blood flow through stenosed vessels with a peripheral plasma layer and applications, Automedica, 18, 271-300 (2000)
[21] Srivastava, V. P., Arterial blood flow through a nonsymmetrical stenosis with applications, Japan. J. Appl. Phys., 34, 6539-6545 (1995)
[22] Srivastava, V. P., Particulate suspension blood flow through stenotic arteries: Effects of hematocrit and stenosis shape, Indian J. Pure Appl. Math, 33, 9, 1953-1960 (2002) · Zbl 1007.92019
[23] Haynes, R. H., Physical basis on dependence of blood viscosity on tube radius, Amer. J. Phys., 198, 1193-1205 (1960)
[24] Bugliarello, G.; Sevilla, J., Velocity distribution and other characteristics of steady and pulsatile blood flow in fine glass tubes, Biorheology, 7, 85-107 (1970)
[25] Srivastava, L. M., Flow of a couple stress fluid through stenotic blood vessels, J. Biomech., 18, 479-485 (1985)
[26] Medhavi, A.; Singh, U. K., A two-layered suspension flow induced by peristaltic waves, Int. J. Fluid Mech. Res., 35, 258-272 (2008)
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