Summary: Mechanistic explanations for the plastic behavior of a wrought magnesium alloy are developed using a combination of experimental and simulation techniques. Parameters affecting the practical sheet formability, such as strain hardening rate, strain rate sensitivity, the degree of anisotropy, and the stresses and strains at fracture, are examined systematically by conducting tensile tests of variously oriented samples at a range of temperatures (room temperature to \(250 ^{\circ}\)C) and strain rates (\(10^{-5}-0.1\) s\(^{-1}\)). Polycrystal plasticity simulations are used to model the observed anisotropy and texture evolution. Strong in-plane anisotropy observed at low temperatures is attributed to the initial texture and the greater than anticipated non-basal cross-slip of dislocations with \(\langle \mathbf a\rangle\) type Burgers vectors. The agreement between the measured and simulated anisotropy and texture is further validated by direct observations of the dislocation microstructures using transmission electron microscopy. The increase in the ductility with temperature is accompanied by a decrease in the flow stress, an increase in the strain rate sensitivity, and a decrease in the normal anisotropy. Polycrystal simulations indicate that an increased activity of non-basal, \(\langle \mathbf {c + a}\rangle\), dislocations provides a self-consistent explanation for the observed changes in the anisotropy with increasing temperature.