Summary: Motivated by a real-life problem, we develop a two-stage cluster sampling with ranked set sampling (TSCRSS) design in the second stage for which we derive an unbiased estimator of the population mean and its variance. An unbiased estimator of the variance of the mean estimator is also derived. It is proved that the TSCRSS is more efficient, in the sense of having smaller variance, than the conventional two-stage cluster simple random sampling in which the second-stage sampling is with replacement. Using a simulation study on a real-life population, we show that the TSCRSS is more efficient than the conventional two-stage cluster sampling when simple random sampling without replacement is used in both stages.