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Subfunctionalization: How often does it occur? How long does it take? (English) Zbl 1111.92044

Summary: The mechanisms responsible for the preservation of duplicate genes have been debated for more than 70 years. Recently, M. Lynch and A. Force [The probability of preservation of a duplicate gene by subfunctionalization. Genetics 154, 459–473 (2000)] have proposed a new explanation: subfunctionalization – after duplication the two gene copies specialize to perform complementary functions. We investigate the probability that subfunctionalization occurs, the amount of time after duplication that it takes for the outcome to be resolved, and the relationship of these quantities to the population size and mutation rates.

MSC:

92D15 Problems related to evolution
92D10 Genetics and epigenetics
Full Text: DOI

References:

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