Summary: We present an exact algorithm for solving the generalized minimum spanning tree problem (GMST). Given an undirected connected graph and a partition of the graph vertices, this problem requires finding a least-cost subgraph spanning at least one vertex out of every subset. In this paper, the GMST is formulated as a minimum spanning tree problem with side constraints and solved exactly by a branch-and-bound algorithm. Lower bounds are derived by relaxing, in a Lagrangian fashion, complicating constraints to yield a modified minimum cost spanning tree problem. An efficient preprocessing algorithm is implemented to reduce the size of the problem. Computational tests on a large set of randomly generated instances with as many as 250 vertices, 1000 edges, and 25 subsets provide evidence that the proposed solution approach is very effective.