×

Coalescent lineage distributions. (English) Zbl 1092.92035

Summary: We study identities for the distribution of the number of edges at time \(t\) back (i.e., measured backwards) in a coalescent tree whose subtrees have no mutations. This distribution is important in the infinitely-many-alleles model of mutation, where every mutation is unique. The model includes, as a special case, the number of edges in a coalescent tree at time \(t\) back when mutation is ignored. The identities take the form of expected values of functions of \(Z_t=e^{iX_t}\), where \(X_t\) is distributed as a standard Brownian motion.
Associated identities are also found for the distributions of the time to the most recent common ancestor, the time until loss of ancestral lines by coalescence or mutation, and the age of a mutation. Hypergeometric functions play an important role in the identities. The identities are of mathematical interest, as well as potentially being formulae to use for numerical integration or simulation to compute distributions that are usually expressed as alternating-sign series expansions, which are difficult to compute.

MSC:

92D15 Problems related to evolution
60J70 Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.)
33C90 Applications of hypergeometric functions
60E99 Distribution theory
60J85 Applications of branching processes
Full Text: DOI

References:

[1] Abramowitz, M. and Stegun, I. (1972). Handbook of Mathematical Functions . Dover, New York. · Zbl 0543.33001
[2] Donnelly, P. J. and Tavaré, S. (1987). The population genealogy of the infinitely many neutral alleles model. J. Math. Biol. 25, 381–391. · Zbl 0636.92008 · doi:10.1007/BF00277163
[3] Ethier, S. N. and Griffiths, R. C. (1993). The transition function of a Fleming–Viot process. Ann. Prob. 21, 1571–1590. · Zbl 0778.60038 · doi:10.1214/aop/1176989131
[4] Ewens, W. J. (1972). The sampling theory of selectively neutral alleles. Theoret. Pop. Biol. 3, 87–112. · Zbl 0245.92009 · doi:10.1016/0040-5809(72)90035-4
[5] Feller, W. (1971). An Introduction to Probability Theory and Its Applications , Vol. 2, 2nd edn. John Wiley, New York. · Zbl 0219.60003
[6] Griffiths, R. (1980). Lines of descent in the diffusion approximation of neutral Wright–Fisher models. Theoret. Pop. Biol. 17, 37–50. · Zbl 0434.92011 · doi:10.1016/0040-5809(80)90013-1
[7] Griffiths, R. C. (1984). Asymptotic line-of-descent distributions. J. Math. Biol. 21, 67–75. · Zbl 0577.92011 · doi:10.1007/BF00275223
[8] Griffiths, R. C. (2003). The frequency spectrum of a mutation, and its age, in a general diffusion model. Theoret. Pop. Biol. 64, 241–251. · Zbl 1104.92045 · doi:10.1016/S0040-5809(03)00075-3
[9] Griffiths, R. C. and Lessard, S. (2005). The Ewens sampling formula and related formulae: combinatorial proofs, extensions to variable population size and applications to ages of alleles. Theoret. Pop. Biol. 68, 167–177. · Zbl 1085.92027 · doi:10.1016/j.tpb.2005.02.004
[10] Griffiths, R. C. and Li, W.-H. (1983). Simulating allele frequencies in a population and the genetic differentiation of populations under mutation pressure. Theoret. Pop. Biol. 32, 19–33. · Zbl 0503.92012 · doi:10.1016/0040-5809(83)90003-5
[11] Griffiths, R. C. and Tavaré, S. (1998). The age of a mutation in a general coalescent tree. Stoch. Models 14, 273–295. · Zbl 0889.92017 · doi:10.1080/15326349808807471
[12] Hudson, R. R. (1991). Gene genealogies and the coalescent process. In Oxford Surveys in Evolutionary Biology , eds D. Futuyama and J. Antonovics, Vol. 7, 2nd edn, Oxford University Press, pp. 1–44.
[13] Kingman, J. F. C. (1982). The coalescent. Stoch. Process. Appl. 13, 235–248. · Zbl 0491.60076 · doi:10.1016/0304-4149(82)90011-4
[14] Kingman, J. F. C. (1993). Poisson Processes (Oxford Stud. Prob. 3 ). Clarendon Press, Oxford. · Zbl 0771.60001
[15] Nordborg, M. (2001). Coalescent theory. In Handbook of Statistical Genetics , eds D. J. Balding, M. Bishop and C. Cannings, John Wiley, Chichester, pp. 179–208.
[16] Saunders, I. W., Tavaré, S. and Watterson, G. A. (1984). On the genealogy of nested subsamples from a haploid population. Adv. Appl. Prob. 16, 471–491. JSTOR: · Zbl 0542.92016 · doi:10.2307/1427285
[17] Tavaré, S. (1984). Line-of-descent and genealogical processes, and their application in population genetics models. Theoret. Pop. Biol. 26, 119–164. · Zbl 0555.92011 · doi:10.1016/0040-5809(84)90027-3
[18] Watterson, G. A. (1984). Lines of descent and the coalescent. Theoret. Pop. Biol. 26, 239–253. · Zbl 0542.92015 · doi:10.1016/0040-5809(84)90025-X
[19] Watterson, G. A. (1996). Motoo Kimura’s use of diffusion theory in population genetics. Theoret. Pop. Biol. 49, 154–188. · Zbl 0845.92012 · doi:10.1006/tpbi.1996.0010
This reference list is based on information provided by the publisher or from digital mathematics libraries. Its items are heuristically matched to zbMATH identifiers and may contain data conversion errors. In some cases that data have been complemented/enhanced by data from zbMATH Open. This attempts to reflect the references listed in the original paper as accurately as possible without claiming completeness or a perfect matching.