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Fitness optimization in a cell division model. (English) Zbl 1079.35030

Summary: We consider a size structured cell population model where a mother cell gives birth to two cells. We know that the asymptotic behavior of the density of cells is given by the solution to an eigenvalue problem. The eigenvector gives the asymptotic shape and the eigenvalue gives the exponential growth rate and so the Maltusian parameter. The Maltusian parameter depends on the division rule for the mother, i.e., symmetric (the two daughter cells have the same size) or asymmetric. We give some example where the symmetrical division is not the best fitted division, i.e., the Maltusian parameter is not optimal.

MSC:

35F10 Initial value problems for linear first-order PDEs
92C37 Cell biology
45K05 Integro-partial differential equations

References:

[1] Bertoin, J.; Gnedin, A. V., Asymptotic laws for nonconservative self-similar fragmentations, Electron. J. Probab., 9, 19, 575-593 (2004) · Zbl 1064.60075
[2] Diekmann, O.; Gyllenberg, M.; Huang, H.; Kirkilionis, M.; Metz, J. A.J.; Thieme, H. R., On the formulation and analysis of general deterministic structured population models. II. Nonlinear theory, J. Math. Biol., 43, 2, 157-189 (2001) · Zbl 1028.92019
[3] Escobedo, M.; Mischler, S.; Rodriguez Ricard, M., On self-similarity and stationary problem for fragmentation and coagulation models, Ann. Inst. H. Poincaré Non Linéaire Anal., 22, 1, 99-125 (2005) · Zbl 1130.35025
[4] Fournier, N.; Mischler, S., Exponential trend to equilibrium for discrete coagulation equations with strong fragmentation and without a balance condition, Proc. Roy Soc. London Ser. A, 460, 2049, 2477-2486 (2004) · Zbl 1170.82349
[5] Horn, R. A.; Johnson, C. R., Matrix Analysis (1985), Cambridge University Press: Cambridge University Press Cambridge, (Chapter 6.3, p. 372) · Zbl 0576.15001
[6] Laurençot, P., Steady states for a fragmentation equation with size diffusion, Banach Center Publ., 66, 211-219 (2004) · Zbl 1100.35111
[7] Metz, J. A.J.; Diekmann, O., The Dynamics of Physiologically Structured Populations, Lecture Notes in Biomath., vol. 68 (1986), Springer-Verlag · Zbl 0614.92014
[8] P. Michel, PhD Thesis, Univ. Paris 9, Dauphine, in preparation; P. Michel, PhD Thesis, Univ. Paris 9, Dauphine, in preparation
[9] P. Michel, S. Mischler, B. Perthame, General relative entropy inequality: an illustration on growth models, J. Math. Pures Appl., in press; P. Michel, S. Mischler, B. Perthame, General relative entropy inequality: an illustration on growth models, J. Math. Pures Appl., in press · Zbl 1085.35042
[10] P. Michel, Existence of a solution to the cell division eigenproblem, Math. Models Methods Appl. Sci., in press; P. Michel, Existence of a solution to the cell division eigenproblem, Math. Models Methods Appl. Sci., in press · Zbl 1094.92023
[11] Perthame, B.; Ryzhik, L., Exponential decay for the fragmentation or cell-division equation, J. Differential Equations, 210, 1, 155-177 (2005) · Zbl 1072.35195
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