Nonparametric estimation for the three-stage irreversible illness death model. (English) Zbl 1060.62595
Summary: We present new nonparametric estimators of the stage-occupation probabilities in the three-stage irreversible illness-death model. These estimators use a fractional risk set and a reweighting approach and are valid under stage-dependent censoring. Using a simulated data set, we compare the behavior of our estimators with previously proposed estimators. We also apply our estimators to data on time to pneumocystis pneumonia and death obtained from an AIDS cohort study.
MSC:
| 62P10 | Applications of statistics to biology and medical sciences; meta analysis |
| 62G05 | Nonparametric estimation |
Keywords:
acquired immunodeficiency syndrome; competing risks; dependent censoring; fractional risk set; human immunodeficiency virus; multistage models; nonparametric estimation; pneumocystis pneumonia; product-limit estimator; survivial analysisReferences:
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