×

Strategies to control the genital herpes epidemic. (English) Zbl 0937.92030

Summary: Genital herpes is a widely prevalent sexually transmitted disease. We introduce a spatial stochastic model to discuss strategies to control the epidemic. Our caricatural description suggests three different directions in order to control the epidemic. First, if the transmission rate is low enough there can be no epidemic. Second, even for a high transmission rate the epidemic will be avoided if the mean time a viral outbreak lasts in a patient is short enough. Finally, the mean time between two viral outbreaks in a patient is useful to control only for an intermediate transmission rate: if the transmission rate is high enough then there will be an epidemic even if the time between two viral outbreaks in a patient is arbitrarily long.

MSC:

92D30 Epidemiology
60K35 Interacting random processes; statistical mechanics type models; percolation theory
Full Text: DOI

References:

[1] Blower, S.; Porco, T.; Darby, G., Predicting and preventing the emergence of antiviral drug resistance in HSV-2, Nature Med., 4, 673 (1998)
[2] R. Durrett, Ten Lectures on Particle Systems, Lecture Notes in Mathematics, vol. 1608, Springer, New York, 1995; R. Durrett, Ten Lectures on Particle Systems, Lecture Notes in Mathematics, vol. 1608, Springer, New York, 1995 · Zbl 0840.60088
[3] Whitley, R.; Gnann, J., Acyclovir: a decade later, New England J. Med., 327, 782 (1992)
[4] A. Wald, L. Corey, R. Cone et al., Frequent genital herpes simplex virus 2 shedding in immunocompetent women, J. Clin. Invest. 99 (1997) 1092; A. Wald, L. Corey, R. Cone et al., Frequent genital herpes simplex virus 2 shedding in immunocompetent women, J. Clin. Invest. 99 (1997) 1092
[5] S. Strauss, M. Seidlin, H. Takiff et al., Effects of oral acyclovir treatment on symptomatic and asymptomatic virus shedding in recurrent genital herpes, Sexually Transmitted Diseases 16 (1989) 107; S. Strauss, M. Seidlin, H. Takiff et al., Effects of oral acyclovir treatment on symptomatic and asymptomatic virus shedding in recurrent genital herpes, Sexually Transmitted Diseases 16 (1989) 107
[6] A. Wald, J. Zeh, G. Barnum et al., Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovir, Ann. Int. Med. 124 (1996) 8; A. Wald, J. Zeh, G. Barnum et al., Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovir, Ann. Int. Med. 124 (1996) 8
[7] Durrett, R.; Liu, X. F., The contact process on a finite set, Ann. Probab., 16, 1158 (1988) · Zbl 0647.60105
[8] van den Berg, J.; Grimmett, G.; Schinazi, R., Dependent random graphs and spatial epidemics, Ann. Appl. Probab., 8, 317 (1998) · Zbl 0946.92028
This reference list is based on information provided by the publisher or from digital mathematics libraries. Its items are heuristically matched to zbMATH identifiers and may contain data conversion errors. In some cases that data have been complemented/enhanced by data from zbMATH Open. This attempts to reflect the references listed in the original paper as accurately as possible without claiming completeness or a perfect matching.