×

Multiple attractors in the response to a vaccination program. (English) Zbl 0699.92016

Summary: Though it is well known that multiple attractors may co-exist in the SEIR (susceptible/exposed/infective/recovered) epidemic model with vital dynamics and seasonally forced oscillations in transmission, the epidemiological significance of multiple attractors has been a subject of debate. I show that the co-existence of attractors is relevant in using the model to study the dynamics of the introduction of a vaccination program into a stable epidemic cycle. Responses to the program may include more than one attractor. The exact timing of the introduction of the program relative to the original epidemic cycle is critical in determining which attractor appears in the response. Analysis of this simple model suggests that the role of multiple attractors in the response to vaccination should be examined in more realistic epidemiological models.

MSC:

92D25 Population dynamics (general)
34C99 Qualitative theory for ordinary differential equations
Full Text: DOI

References:

[1] Anderson, R. M., Directly transmitted viral and bacterial infections of man, (Anderson, R. M., Population Dynamics of Infectious Diseases (1982), Chapman & Hall: Chapman & Hall London), 1-37
[2] Anderson, R. M.; May, R. M., Directly transmitted infectious diseases: Control by vaccination, Science, 215, 1053-1060 (1982) · Zbl 1225.37099
[3] Anderson, R. M.; May, R. M., Age-related changes in the rate of disease transmission: Implications for the design of vaccination programmes, J. Hyg, 94, 365-436 (1985)
[4] Aron, J. L., Simple versus complex epidemiological models, (Levin, S.; Hallam, T. G.; Gross, L., Applied Mathematical Ecology (1989), Springer-Verlag: Springer-Verlag Berlin), 176-192
[5] Aron, J. L.; Schwartz, I. B., Seasonality and period-doubling bifurcations in an epidemic model, J. Theor. Biol, 110, 665-679 (1984)
[6] Fine, P. E.M.; Clarkson, J. A., Measles in England and Wales. III. Assessing published predictions of the impact of vaccination on incidence, Int. J. Epidemiol, 12, 332-339 (1983)
[7] Greenhalgh, D., Analytical threshold and stability results on age-structured epidemic models with vaccination, Theor. Pop. Biol, 33, 266-290 (1988) · Zbl 0657.92008
[8] Grossman, Z., Oscillatory phenomena in a model of infectious diseases, Theor. Pop. Biol, 18, 204-243 (1980) · Zbl 0457.92020
[9] Hethcote, H. W., Measles and rubella in the United States, Amer. J. Epidemiol, 117, 2-13 (1983)
[10] Kahaner, D., PLOD (PLotted solutions of Ordinary Differential equations) (1988), National Bureau of Standards: National Bureau of Standards Gaithersburg, MD
[11] Olsen, L. F.; Truty, G. L.; Schaffer, W. M., Oscillations and chaos in epidemics: A nonlinear dynamic study of six childhood diseases in Copenhagen, Theor. Pop. Biol, 33, 344-370 (1988) · Zbl 0639.92012
[12] Schenzle, D., An age-structured model of pre- and post-vaccination measles transmission, IMA J. Math. Appl. Med. Biol, 1, 169-191 (1984) · Zbl 0611.92021
[13] Schwartz, I. B., Multiple stable recurrent outbreaks and predictability in seasonally forced nonlinear epidemic models, J. Math. Biol, 21, 347-361 (1985) · Zbl 0558.92013
[14] Schwartz, I. B.; Smith, H. L., Infinite subharmonic bifurcation in an SEIR epidemic model, J. Math. Biol, 18, 233-253 (1983) · Zbl 0523.92020
[15] Yorke, J. A., DYNAMICS, a program for the IBM PC (1988), University of Maryland: University of Maryland College Park, MD
[16] Yorke, J. A.; Nathanson, N.; Pianigiani, G.; Martin, J., Seasonality and the requirements for perpetuation and eradication of viruses in populations, Amer. J. Epidemiol, 109, 103-123 (1979)
This reference list is based on information provided by the publisher or from digital mathematics libraries. Its items are heuristically matched to zbMATH identifiers and may contain data conversion errors. In some cases that data have been complemented/enhanced by data from zbMATH Open. This attempts to reflect the references listed in the original paper as accurately as possible without claiming completeness or a perfect matching.