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The analysis of cancer chemoprevention experiments. (English) Zbl 0623.62100

This paper is concerned with the analysis of certain cancer chemoprevention experiments that involve type I censoring. In experiments of this nature, two common response variables are the number of induced cancers and the rate at which they develop. In this study we assume that the number of induced tumors and their times to detection are described by the Poisson and gamma distributions, respectively. Using the method of maximum likelihood, we discuss a procedure for estimating the parameters characterizing these two distributions. We apply standard techniques in order to construct a confidence region and conduct a hypothesis test concerning the parameters of interest.

MSC:

62P10 Applications of statistics to biology and medical sciences; meta analysis
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