A Lagrange-Gamma multihit dose-response model for risk assessment. (English) Zbl 0598.62142
This paper investigates the use of Lagrange-gamma multihit dose-response model to perform toxic chemical risk assessment. A biological interpolation of the model in terms of the occurrence of k ”hits” to cause toxic response and a statistical interpretation in terms of a Lagrange-gamma tolerance density are given. The parameters of the model are obtained by the method of maximum likelihood and are used to estimate a virtual safe dose.
MSC:
| 62P10 | Applications of statistics to biology and medical sciences; meta analysis |
| 92C50 | Medical applications (general) |
Keywords:
Lagrange-gamma multihit dose-response model; toxic chemical risk assessment; Lagrange-gamma tolerance density; maximum likelihood; virtual safe doseReferences:
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