EHD2

EHD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QPT, 4CID
Identifiers
Aliases	EHD2, PAST2, EH domain containing 2
External IDs	OMIM: 605890; MGI: 2154274; HomoloGene: 22825; GeneCards: EHD2; OMA:EHD2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,743,134 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	15,701,492 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; subcutaneous adipose tissue; ; left coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; right lung; ; canal of the cervix;
	Top expressed in
	ascending aorta; ; aortic valve; ; brown adipose tissue; ; left lung; ; right lung; ; left lung lobe; ; right lung lobe; ; ankle; ; subcutaneous adipose tissue; ; white adipose tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; protein domain specific binding; nucleotide binding; calcium ion binding; GTP binding; hydrolase activity; ATP binding; nucleic acid binding; identical protein binding;
Cellular component	caveola; endosome membrane; recycling endosome membrane; cytoplasm; cytosol; nucleus; membrane; perinuclear region of cytoplasm; endosome; extrinsic component of membrane; extracellular exosome; plasma membrane; microtubule cytoskeleton; intercellular bridge;
Biological process	blood coagulation; endocytosis; protein localization to plasma membrane; plasma membrane tubulation; positive regulation of myoblast fusion; positive regulation of endocytic recycling; actin cytoskeleton organization; cortical actin cytoskeleton organization; endocytic recycling;
	Sources:Amigo / QuickGO
Orthologs
	30846
	259300
	ENSG00000024422
	ENSMUSG00000074364
	Q9NZN4
	Q8BH64
	NM_014601
	NM_153068
	NP_055416
	NP_694708
	Wikidata
View/Edit Human	View/Edit Mouse

EH-domain containing 2, also known as EHD2, is a human gene^[5] belonging to the EHD protein family.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000024422 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074364 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EHD2 EH-domain containing 2".

Pohl U, Smith JS, Tachibana I, et al. (2000). "EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins". Genomics. 63 (2): 255–62. doi:10.1006/geno.1999.6087. PMID 10673336.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Guilherme A, Soriano NA, Bose S, et al. (2004). "EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton". J. Biol. Chem. 279 (11): 10593–605. doi:10.1074/jbc.M307702200. PMID 14676205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Park SY, Ha BG, Choi GH, et al. (2004). "EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment". Biochemistry. 43 (23): 7552–62. doi:10.1021/bi049970f. PMID 15182197.
Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
Guilherme A, Soriano NA, Furcinitti PS, Czech MP (2004). "Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes". J. Biol. Chem. 279 (38): 40062–75. doi:10.1074/jbc.M401918200. PMID 15247266.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

Overview of all the structural information available in the PDB for UniProt: Q8BH64 (Mouse EH domain-containing protein 2 (EHD2)) at the PDBe-KB.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000024422 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074364 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EHD2 EH-domain containing 2".

[1]

References

Further reading

External links