ANKRD15

KANK1
Identifiers
Aliases	KANK1, ANKRD15, CPSQ2, KANK, KN motif and ankyrin repeat domains 1
External IDs	OMIM: 607704; MGI: 2147707; HomoloGene: 17706; GeneCards: KANK1; OMA:KANK1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	746,105 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	25,411,860 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; Descending thoracic aorta; ; ascending aorta; ; cardiac muscle tissue of right atrium; ; popliteal artery; ; tibial arteries; ; gingival epithelium; ; myocardium of left ventricle; ; saphenous vein; ; right auricle;
	Top expressed in
	fourth ventricle; ; choroid plexus of fourth ventricle; ; hand; ; interventricular septum; ; Dermatocranium; ; membranous bone; ; basilar part of occipital bone; ; ascending aorta; ; aortic valve; ; inner renal medulla;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	beta-catenin binding; protein binding;
Cellular component	cytoplasm; cell projection; membrane; plasma membrane; ruffle membrane; nucleus;
Biological process	negative regulation of neuron projection development; regulation of transcription, DNA-templated; negative regulation of actin filament polymerization; negative regulation of ruffle assembly; negative regulation of Rho protein signal transduction; positive regulation of wound healing; transcription, DNA-templated; positive regulation of Wnt signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of cell migration; negative regulation of lamellipodium morphogenesis; negative regulation of substrate adhesion-dependent cell spreading; regulation of establishment of cell polarity; positive regulation of canonical Wnt signaling pathway; regulation of Rho protein signal transduction; glomerular visceral epithelial cell migration; cell population proliferation; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	23189
	107351
	ENSG00000107104
	ENSMUSG00000032702
	Q14678
	n/a
NM_001256876; NM_001256877; NM_015158; NM_153186; NM_001354331;
	NM_001354332; NM_001354333; NM_001354334; NM_001354335; NM_001354336; NM_001354337; NM_001354338; NM_001354339; NM_001354340; NM_001354341; NM_001354342; NM_001354343; NM_001354344
	NM_181404; NM_001348180
NP_001243805; NP_001243806; NP_055973; NP_694856; NP_001341260;
	NP_001341261; NP_001341262; NP_001341263; NP_001341264; NP_001341265; NP_001341266; NP_001341267; NP_001341268; NP_001341269; NP_001341270; NP_001341271; NP_001341272; NP_001341273
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.^[5]^[6]^[7]

This gene encodes a protein containing four ankyrin repeat domains in its C-terminus. The suggested role for this protein is in tumorigenesis of renal cell carcinoma. Two alternatively spliced transcript variants encoding different isoforms have been identified.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107104 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032702 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sarkar S, Roy BC, Hatano N, Aoyagi T, Gohji K, Kiyama R (Sep 2002). "A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma". J Biol Chem. 277 (39): 36585–91. doi:10.1074/jbc.M204244200. PMID 12133830.
^ Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". Biochim Biophys Acta. 1780 (2): 128–33. doi:10.1016/j.bbagen.2007.09.017. PMID 17996375.
^ ^a ^b "Entrez Gene: ANKRD15 ankyrin repeat domain 15".

External links

Human KANK1 genome location and KANK1 gene details page in the UCSC Genome Browser.

Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Roy BC, Aoyagi T, Sarkar S, et al. (2005). "Pathological characterization of Kank in renal cell carcinoma". Exp. Mol. Pathol. 78 (1): 41–8. doi:10.1016/j.yexmp.2004.08.012. PMID 15596059.
Wang Y, Onishi Y, Kakinuma N, et al. (2005). "Alternative splicing of the human Kank gene produces two types of Kank protein". Biochem. Biophys. Res. Commun. 330 (4): 1247–53. doi:10.1016/j.bbrc.2005.03.106. PMID 15823577.
Wang Y, Kakinuma N, Zhu Y, Kiyama R (2007). "Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin". J. Cell Sci. 119 (Pt 19): 4002–10. doi:10.1242/jcs.03169. PMID 16968744. S2CID 14196261.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107104 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032702 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12133830-5] Sarkar S, Roy BC, Hatano N, Aoyagi T, Gohji K, Kiyama R (Sep 2002). "A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma". J Biol Chem. 277 (39): 36585–91. doi:10.1074/jbc.M204244200. PMID 12133830.

[pmid17996375-6] Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". Biochim Biophys Acta. 1780 (2): 128–33. doi:10.1016/j.bbagen.2007.09.017. PMID 17996375.

[entrez-7] "Entrez Gene: ANKRD15 ankyrin repeat domain 15".

[1]

References

External links

Further reading