The Cardinals (9–3–2) were the runner-up in the Eastern Conference, finishing a half game behind the Cleveland Browns (10–3–1), who won the NFL championship game on December 27. The Cardinals tied the Browns in Cleveland in September and defeated them in St. Louis in December.
Note: Intra-conference opponents are in bold text.
^ The game with the Baltimore Colts on October 12 was originally scheduled for St. Louis, but was moved to Baltimore due to the baseball Cardinals' participation in the World Series.
TV announcers (CBS): Jack Drees (STL) (second half) and Ken Coleman (CLE) (first half) (play-by-play), Bill Fischer (STL) (second half) and Warren Lahr (CLE) (first half) (color commentators)
TV announcers (CBS): Ken Coleman (CLE) (second half) and Jack Drees (STL) (first half) (play-by-play), Warren Lahr (CLE) (second half) and Bill Fischer (STL) (first half) (color commentators)