Pages that link to "Q27657679"
Jump to navigation
Jump to search
The following pages link to A frequent kinase domain mutation that changes the interaction between PI3K and the membrane (Q27657679):
Displaying 50 items.
- Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (Q7117823) (← links)
- Phosphoinositide-3-kinase regulatory subunit 1 (Q7119385) (← links)
- Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions (Q24339544) (← links)
- Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage (Q24603171) (← links)
- Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA (Q24632718) (← links)
- Phosphoinositides: tiny lipids with giant impact on cell regulation (Q27012953) (← links)
- The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas (Q27021883) (← links)
- Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant (Q27320874) (← links)
- The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors (Q27659013) (← links)
- Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein (Q27659586) (← links)
- Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn region (Q27666219) (← links)
- Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism (Q27667112) (← links)
- Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases (Q27675831) (← links)
- Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ Isozymes (Q27678692) (← links)
- Crystal Structures of PI3Kα Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design (Q27684223) (← links)
- Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design (Q27684749) (← links)
- KDM1 class flavin-dependent protein lysine demethylases (Q28084876) (← links)
- Identification of novel piperazinylquinoxaline derivatives as potent phosphoinositide 3-kinase (PI3K) inhibitors (Q28482245) (← links)
- Anticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approaches (Q28540187) (← links)
- The emerging mechanisms of isoform-specific PI3K signalling (Q29617954) (← links)
- Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer (Q30009083) (← links)
- The next generation of metastatic melanoma: uncovering the genetic variants for anti-BRAF therapy response (Q30384301) (← links)
- Activating mutations in TOR are in similar structures as oncogenic mutations in PI3KCalpha (Q30437618) (← links)
- Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS). (Q30538272) (← links)
- Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs) (Q30557755) (← links)
- Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design (Q33653223) (← links)
- Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS. (Q33716552) (← links)
- Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH). (Q33726416) (← links)
- Small-molecule inhibitors of the PI3K signaling network (Q33883982) (← links)
- (+)-2-(1-Hydroxyl-4-oxocyclohexyl) ethyl caffeate suppresses solar UV-induced skin carcinogenesis by targeting PI3K, ERK1/2, and p38. (Q34016856) (← links)
- Functional and genomic analyses of alpha-solenoid proteins (Q34039121) (← links)
- Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells (Q34060558) (← links)
- Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha (Q34100548) (← links)
- A human immunodeficiency caused by mutations in the PIK3R1 gene (Q34129000) (← links)
- PI3K: from the bench to the clinic and back (Q34195495) (← links)
- Structural basis of nSH2 regulation and lipid binding in PI3Kα. (Q34221876) (← links)
- A biochemical mechanism for the oncogenic potential of the p110β catalytic subunit of phosphoinositide 3-kinase (Q34358850) (← links)
- Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency (Q34380652) (← links)
- PI3Kα inhibitors that inhibit metastasis (Q34416746) (← links)
- The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias (Q34465221) (← links)
- Gain-of-function mutations and immunodeficiency: at a loss for proper tuning of lymphocyte signaling (Q34495699) (← links)
- Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity (Q34524060) (← links)
- Role of E542 and E545 missense mutations of PIK3CA in breast cancer: a comparative computational approach (Q34539092) (← links)
- A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas (Q34694344) (← links)
- Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase. (Q34755265) (← links)
- Identification of mutations in distinct regions of p85 alpha in urothelial cancer (Q35075756) (← links)
- Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival (Q35096551) (← links)
- Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α (Q35161212) (← links)
- Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains (Q35180699) (← links)
- Immunological loss-of-function due to genetic gain-of-function in humans: autosomal dominance of the third kind (Q35190461) (← links)