Excitatory neuron-specific SHP2-ERK signaling network regulates synaptic plasticity and memory (Q92147972)

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27 April 2020

title

Excitatory neuron-specific SHP2-ERK signaling network regulates synaptic plasticity and memory (English)

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27 April 2020

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27 April 2020

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27 April 2020

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27 April 2020

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27 April 2020

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27 April 2020

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27 April 2020

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27 April 2020

1 reference

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27 April 2020

Chae-Seok Lim

1 reference

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27 April 2020

Hyopil Kim

1 reference

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27 April 2020

Sang Jeong Kim

1 reference

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27 April 2020

Jung-Woong Kim

1 reference

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27 April 2020

Yong Gyu Kim

1 reference

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27 April 2020

Ja Eun Choi

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27 April 2020

Jisu Lee

1 reference

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27 April 2020

Alcino J Silva

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27 April 2020

publication date

5 March 2019

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27 April 2020

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27 April 2020

volume

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27 April 2020

issue

571

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describes a project that uses

27 April 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6800025/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Noonan syndrome-associated SHP2 mutation differentially modulates the expression of postsynaptic receptors according to developmental maturation.

23 February 2021

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Inhibitory suppression of heterogeneously tuned excitation enhances spatial coding in CA1 place cells

23 February 2021

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23 February 2021

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Increased Src Family Kinase Activity Disrupts Excitatory Synaptic Transmission and Impairs Remote Fear Memory in Forebrain Shp2-Deficient Mice.

23 February 2021

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Severe Intellectual Disability and Enhanced Gamma-Aminobutyric Acidergic Synaptogenesis in a Novel Model of Rare RASopathies.

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Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking

23 February 2021

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A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I.

23 February 2021

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Impaired learning and memory in CD38 null mutant mice

23 February 2021

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SHP2 sails from physiology to pathology.

23 February 2021

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Dysregulation of astrocyte extracellular signaling in Costello syndrome

23 February 2021

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Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice

23 February 2021

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Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.

23 February 2021

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Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons

23 February 2021

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Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway

23 February 2021

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Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons

23 February 2021

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Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial

23 February 2021

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Learning and memory in children with Noonan syndrome

23 February 2021

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23 February 2021

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Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2.

23 February 2021

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Fast gapped-read alignment with Bowtie 2

23 February 2021

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Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons

23 February 2021

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Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins

23 February 2021

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Noonan Syndrome: Clinical Features, Diagnosis, and Management Guidelines

23 February 2021

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Neurofibromin regulates corticostriatal inhibitory networks during working memory performance

23 February 2021

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Ras and Rap signaling in synaptic plasticity and mental disorders

23 February 2021

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Post-training reversible inactivation of the hippocampus enhances novel object recognition memory

23 February 2021

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The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

23 February 2021

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Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation

23 February 2021

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Neurofibromin regulation of ERK signaling modulates GABA release and learning

23 February 2021

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Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases

23 February 2021

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Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial

23 February 2021

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23 February 2021

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Stops along the RAS pathway in human genetic disease

23 February 2021

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Noonan syndrome and related disorders: genetics and pathogenesis

23 February 2021

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Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes

23 February 2021

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

23 February 2021

1 reference

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Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

23 February 2021

1 reference

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Acquiring signalling specificity from the cytokine receptor gp130.

23 February 2021

1 reference

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

23 February 2021

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

23 February 2021

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Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1

23 February 2021

1 reference

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Regulation of the mitogen-activated protein kinase signaling pathway by SHP2.

23 February 2021

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The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors

23 February 2021

1 reference

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Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

23 February 2021

1 reference

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The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory.

23 February 2021

1 reference

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A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

23 February 2021

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Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

23 February 2021

1 reference

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Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

23 February 2021

1 reference

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The protein tyrosine phosphatase SHP-2 is expressed in glial and neuronal progenitor cells, postmitotic neurons and reactive astrocytes

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6800025

Subregion- and cell type-restricted gene knockout in mouse brain

23 February 2021

1 reference

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Regional expression and subcellular localization of the tyrosine-specific phosphatase SH-PTP2 in the adult human nervous system

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6800025

Localization and subcellular distribution of SH-PTP2, a protein-tyrosine phosphatase with Src homology-2 domains, in rat brain

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6800025

10.1126/SCISIGNAL.AAU5755

23 February 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30837304%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30837304%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

PubMed publication ID

30837304

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30837304%20AND%20SRC:MED&resulttype=core&format=json