Emodin protects against diabetic cardiomyopathy by regulating the AKT/GSK-3β signaling pathway in the rat model (Q85331689)

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16 February 2020

title

Emodin protects against diabetic cardiomyopathy by regulating the AKT/GSK-3β signaling pathway in the rat model (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25232702%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

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diabetic cardiomyopathy

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Zhiqin Wu

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25232702%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Qingwei Chen

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16 February 2020

Dazhi Ke

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16 February 2020

Guiqiong Li

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16 February 2020

Wei Deng

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16 February 2020

language of work or name

English

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publication date

17 September 2014

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16 February 2020

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16 February 2020

volume

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16 February 2020

issue

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16 February 2020

page(s)

14782-14793

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Creative Commons Attribution 4.0 International

16 February 2020

start time

17 September 2014

1 reference

April 2022 Public Data File from Crossref

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12 December 2020

NTP Toxicology and Carcinogenesis Studies of EMODIN (CAS NO. 518-82-1) Feed Studies in F344/N Rats and B6C3F1 Mice.

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12 December 2020

Diabetic cardiomyopathy

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12 December 2020

Diabetes and the global burden of non-communicable disease

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12 December 2020

Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats

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12 December 2020

The pathobiology of diabetic complications: a unifying mechanism

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12 December 2020

Inhibition of the replication of hepatitis B virus in vitro by emodin.

1 reference

12 December 2020

Inhibition of phosphorylation of p38 MAPK involved in the protection of nephropathy by emodin in diabetic rats

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12 December 2020

Diabetic cardiomyopathy and its prevention by metallothionein: experimental evidence, possible mechanisms and clinical implications

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12 December 2020

Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options

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12 December 2020

Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling

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12 December 2020

Hyperglycemic crises in adult patients with diabetes

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12 December 2020

Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus

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12 December 2020

Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice

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12 December 2020

Rodent models of diabetic cardiomyopathy.

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12 December 2020

Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide

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12 December 2020

Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo

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12 December 2020

Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway

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12 December 2020

Diabetic cardiomyopathy, causes and effects

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12 December 2020

Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice

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12 December 2020

Early combined treatment with sildenafil and adipose-derived mesenchymal stem cells preserves heart function in rat dilated cardiomyopathy

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12 December 2020

Inhibition of Aldehyde Dehydrogenase 2 by Oxidative Stress Is Associated with Cardiac Dysfunction in Diabetic Rats

1 reference

12 December 2020

Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies

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12 December 2020

Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy

1 reference

12 December 2020

Mitochondrial dysfunction in diabetic cardiomyopathy

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12 December 2020

Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets

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12 December 2020

Overexpression of human C-reactive protein exacerbates left ventricular remodeling in diabetic cardiomyopathy

1 reference

12 December 2020

Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment.

1 reference

12 December 2020

Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes

1 reference

12 December 2020

Heart disease and stroke statistics--2012 update: a report from the American Heart Association

1 reference

12 December 2020

Emodin prevents intrahepatic fat accumulation, inflammation and redox status imbalance during diet-induced hepatosteatosis in rats

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12 December 2020

Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function

1 reference

12 December 2020

Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data

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12 December 2020

Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis

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12 December 2020

The critical role of Astragalus polysaccharides for the improvement of PPARα [ correction of PPRAα]-mediated lipotoxicity in diabetic cardiomyopathy

1 reference

12 December 2020

Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms

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12 December 2020

Global burden of disease--where does diabetes mellitus fit in?

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12 December 2020

Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker

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12 December 2020

Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.

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12 December 2020

Characterization of apoptosis induced by emodin and related regulatory mechanisms in human neuroblastoma cells

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12 December 2020

Emodin-6-O-β-D--glucoside inhibits high-glucose-induced vascular inflammation

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12 December 2020

Emodin suppresses hyperglycemia-induced proliferation and fibronectin expression in mesangial cells via inhibiting cFLIP

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12 December 2020

Emodin inhibits LPS-induced inflammatory response by activating PPAR-γ in mouse mammary epithelial cells

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12 December 2020

Emodin up-regulates glucose metabolism, decreases lipolysis, and attenuates inflammation in vitro

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12 December 2020

New type of cardiomyopathy associated with diabetic glomerulosclerosis

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12 December 2020

Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections

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12 December 2020

10.3390/MOLECULES190914782

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25232702%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25232702%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

25232702

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25232702%20AND%20SRC:MED&resulttype=core&format=json