The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO (Q84115558)

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1 February 2020

title

The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO (English)

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1 February 2020

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1 February 2020

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1 February 2020

J Duque-Afonso

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1 February 2020

A Yalcin

series ordinal

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1 February 2020

M Abdelkarim

series ordinal

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1 February 2020

M Lübbert

series ordinal

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publication date

16 May 2011

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1 February 2020

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volume

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issue

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page(s)

3062-3072

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Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

1 February 2020

cites work

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Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

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Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression.

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Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes

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Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

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MLL translocations, histone modifications and leukaemia stem-cell development

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Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.

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The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia

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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

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Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation

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AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

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