A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination (Q77398644)

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5 December 2019

title

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination (English)

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5 December 2019

Y Gao

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5 December 2019

J Chaudhuri

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5 December 2019

C Zhu

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5 December 2019

L Davidson

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D T Weaver

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5 December 2019

F W Alt

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5 December 2019

publication date

1 September 1998

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5 December 2019

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volume

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issue

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5 December 2019

page(s)

367-376

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Intact G2-phase checkpoint in cells of a human cell line lacking DNA-dependent protein kinase activity.

5 December 2019

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Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint

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V(D)J recombination gets a break

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The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

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DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

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DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

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The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement

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A link between double-strand break-related repair and V(D)J recombination: the scid mutation

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Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

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DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

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Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions

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7 January 2021

Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit

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7 January 2021

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen

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Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

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The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

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Homology-directed repair is a major double-strand break repair pathway in mammalian cells

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The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination

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7 January 2021

Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks

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7 January 2021

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

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7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

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7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

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Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

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Identifiers

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5 December 2019

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