Uncoupling of the order of the S and M phases: effects of staurosporine on human cell cycle kinases (Q74010958)

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8 November 2019

title

Uncoupling of the order of the S and M phases: effects of staurosporine on human cell cycle kinases (English)

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8 November 2019

Stokke T

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8 November 2019

Smedshammer L

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8 November 2019

Jonassen TS

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8 November 2019

Blomhoff HK

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8 November 2019

Skarstad K

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8 November 2019

Steen HB

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8 November 2019

publication date

1 May 1997

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8 November 2019

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8 November 2019

volume

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8 November 2019

issue

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8 November 2019

page(s)

197-218

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Cell cycle. Dams and sluices.

8 November 2019

cites work

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12 December 2020

Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases

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Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans

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Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2.

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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

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P53 expression is associated with a high-degree of tumor DNA aneuploidy and incidence of p53 gene mutation, and is localized to the aneuploid component in colorectal carcinomas.

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A model on the origin and evolution of DNA aneuploidy

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest

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Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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p53 functions as a cell cycle control protein in osteosarcomas

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The cell cycle as a cdc2 cycle

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Universal control mechanism regulating onset of M-phase

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Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase

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Molecular Genetic Studies of Tumor suppressor Gene Regions on chromosomes 13 and 17 in Colorectal Tumors

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

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Effects of an Rb mutation in the mouse

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Staurosporine suppresses replicon initiation in mammalian cells

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Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates

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Checkpoints: controls that ensure the order of cell cycle events

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Staurosporine- and radiation-induced G2-phase cell cycle blocks are equally released by caffeine

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The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

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12 December 2020

Distinct roles for cyclin-dependent kinases in cell cycle control

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12 December 2020

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

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12 December 2020

Effect of staurosporine on MOLT-4 cell progression through G2 and on cytokinesis

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12 December 2020

Cell Polyploidy: Its Relation to Tissue Growth and Function

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12 December 2020

Physical interaction of the retinoblastoma protein with human D cyclins

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12 December 2020

Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases

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12 December 2020

Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2

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12 December 2020

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

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12 December 2020

Activation of cyclin A-dependent protein kinases during apoptosis

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12 December 2020

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

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12 December 2020

Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.

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12 December 2020

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

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12 December 2020

Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis

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12 December 2020

The fraction of cells in G1 with bound retinoblastoma protein increases with the duration of the cell cycle

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12 December 2020

Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit

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12 December 2020

Inhibition of cAMP-dependent protein kinase plays a key role in the induction of mitosis and nuclear envelope breakdown in mammalian cells

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12 December 2020

Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210

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12 December 2020

Requirement for a functional Rb-1 gene in murine development

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12 December 2020

Creative blocks: cell-cycle checkpoints and feedback controls

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12 December 2020

The retinoblastoma gene product is bound in the nucleus in early G1 phase

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12 December 2020

Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein

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12 December 2020

Establishment in monolayer culture and characterization of four human melanoma cell lines

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12 December 2020

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit

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12 December 2020

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

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12 December 2020

Regulation of p34cdc2 protein kinase during mitosis

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12 December 2020

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

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12 December 2020

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

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12 December 2020

Requirement of mosXe protein kinase for meiotic maturation of Xenopus oocytes induced by a cdc2 mutant lacking regulatory phosphorylation sites

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12 December 2020

Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycle

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12 December 2020

Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase

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12 December 2020

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

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12 December 2020

Cell cycle-specific expression and nuclear binding of DNA polymerase alpha

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12 December 2020

The kinase inhibitor staurosporine induces G1 arrest at two points: effect on retinoblastoma protein phosphorylation and cyclin-dependent kinase 2 in normal and transformed cells.

1 reference

12 December 2020

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein

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12 December 2020

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

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12 December 2020

p53 mutations in colorectal cancer

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12 December 2020

A family of human cdc2-related protein kinases

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12 December 2020

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

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12 December 2020

A new screening test for antimitotic compounds using the universal M phase-specific protein kinase, p34cdc2/cyclin Bcdc13, affinity-immobilized on p13suc1-coated microtitration plates

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12 December 2020

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines

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12 December 2020

Specific enzymatic dephosphorylation of the retinoblastoma protein

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12 December 2020

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

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12 December 2020

Feedback control of mitosis in budding yeast

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12 December 2020

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1

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12 December 2020

Flow cytometric discrimination of mitotic cells: resolution of M, as well as G1, S, and G2 phase nuclei with mithramycin, propidium iodide, and ethidium bromide after fixation with formaldehyde

1 reference

12 December 2020

p21 is a universal inhibitor of cyclin kinases

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12 December 2020

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1 reference

12 December 2020

10.1111/J.1365-2184.1997.TB00935.X

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9420612%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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