Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F (Q64262476)

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24 April 2020

title

Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F (English)

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24 April 2020

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GOA release 2020-03-11

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24 April 2020

Vanessa Clerico Mosina

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24 April 2020

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24 April 2020

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24 April 2020

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24 April 2020

author name string

Carolina Alvadia

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Novandy K Lim

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Vanessa Clerico Mosina

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Gert T Oostergetel

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Raimund Dutzler

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Cristina Paulino

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language of work or name

English

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publication date

20 February 2019

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volume

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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

24 April 2020

cites work

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12 December 2020

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Lipid flippases and their biological functions.

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Membrane reconstitution of ABC transporters and assays of translocator function.

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TMEM16A confers receptor-activated calcium-dependent chloride conductance

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TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity

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Expression cloning of TMEM16A as a calcium-activated chloride channel subunit

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Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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A practical guide to the preparation of Ca(2+) buffers

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Calcium-dependent phospholipid scrambling by TMEM16F

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A versatile and efficient high-throughput cloning tool for structural biology

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Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome.

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Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome

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Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

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Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology

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Prevention of overfitting in cryo-EM structure determination

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12 December 2020

TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation

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12 December 2020

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members

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12 December 2020

Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?

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High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

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Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel.

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12 December 2020

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.

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12 December 2020

X-ray structure of a calcium-activated TMEM16 lipid scramblase

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12 December 2020

Identification of a lipid scrambling domain in ANO6/TMEM16F.

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12 December 2020

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes.

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12 December 2020

Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms.

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12 December 2020

CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

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12 December 2020

A TMEM16F point mutation causes an absence of canine platelet TMEM16F and ineffective activation and death-induced phospholipid scrambling

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12 December 2020

A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid

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12 December 2020

Phospholipid Scramblases

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12 December 2020

Exposure of phosphatidylserine on the cell surface

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12 December 2020

Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane

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12 December 2020

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

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12 December 2020

Structural basis for phospholipid scrambling in the TMEM16 family

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12 December 2020

Lipid somersaults: Uncovering the mechanisms of protein-mediated lipid flipping

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12 December 2020

A Fluorescence-based Assay of Phospholipid Scramblase Activity

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12 December 2020

Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A

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12 December 2020

Independent activation of distinct pores in dimeric TMEM16A channels

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12 December 2020

The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel

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12 December 2020

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2.

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12 December 2020

Anoctamins/TMEM16 Proteins: Chloride Channels Flirting with Lipids and Extracellular Vesicles

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12 December 2020

Atomistic insight into lipid translocation by a TMEM16 scramblase.

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12 December 2020

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

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12 December 2020

Focus: The interface between data collection and data processing in cryo-EM.

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12 December 2020

Characterization of the scrambling domain of the TMEM16 family.

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12 December 2020

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A.

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12 December 2020

UCSF ChimeraX: Meeting Modern Challenges in Visualization and Analysis.

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12 December 2020

Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase.

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12 December 2020

Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid.

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12 December 2020

Cryo-EM structures of the TMEM16A calcium-activated chloride channel.

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12 December 2020

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM.

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12 December 2020

Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin

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12 December 2020

Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F.

1 reference

12 December 2020

The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel

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12 December 2020

Single-molecule analysis of phospholipid scrambling by TMEM16F.

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12 December 2020

Known structures and unknown mechanisms of TMEM16 scramblases and channels.

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12 December 2020

Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases

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12 December 2020

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

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12 December 2020

New tools for automated high-resolution cryo-EM structure determination in RELION-3

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12 December 2020

Structural basis of Ca-dependent activation and lipid transport by a TMEM16 scramblase

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12 December 2020

Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

1 reference

12 December 2020

Identifiers

DOI

10.7554/ELIFE.44365

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30785399%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30785399%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

PubMed publication ID

30785399

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30785399%20AND%20SRC:MED&resulttype=core&format=json