Hedgehog Signaling Regulates Taste Organs and Oral Sensation: Distinctive Roles in the Epithelium, Stroma, and Innervation (Q64084362)

PubMed Central

full work available at URL

1 September 2020

January 2019

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https://www.mdpi.com/1422-0067/20/6/1341

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published in

International Journal of Molecular Sciences

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1 September 2020

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1341

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Creative Commons Attribution

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1 September 2020

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The relationship between the spleen colony-forming cell and the haemopoietic stem cell

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12 December 2020

Regeneration of fungiform taste buds: temporal and spatial characteristics

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12 December 2020

Renewal of cells within taste buds

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12 December 2020

Regeneration of taste buds after reinnervation of a denervated tongue papilla by a normally nongustatory nerve

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12 December 2020

Expression of the neural cell adhesion molecule (NCAM) and polysialic acid during taste bud degeneration and regeneration

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12 December 2020

Morphometric and immunocytochemical assessment of fungiform taste buds after interruption of the chorda-lingual nerve

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12 December 2020

Recovery of chorda tympani nerve function following injury

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12 December 2020

Organ cultures of embryonic rat tongue support tongue and gustatory papilla morphogenesis in vitro without intact sensory ganglia.

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12 December 2020

Chemosensory and somatosensory regeneration after lingual nerve repair in humans.

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12 December 2020

Neural cell adhesion molecule, neuron-specific enolase and calcitonin gene-related peptide immunoreactivity in hamster taste buds after chorda tympani/lingual nerve denervation

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12 December 2020

Initial innervation of embryonic rat tongue and developing taste papillae: nerves follow distinctive and spatially restricted pathways.

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12 December 2020

Expression of Mash1 in basal cells of rat circumvallate taste buds is dependent upon gustatory innervation

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12 December 2020

Expression of sonic hedgehog, patched, and Gli1 in developing taste papillae of the mouse

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12 December 2020

Expression of the neural cell adhesion molecule in mouse taste buds after denervation

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12 December 2020

Neonatal chorda tympani transection permanently disrupts fungiform taste bud and papilla structure in the rat.

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12 December 2020

Morphological and functional study of regenerated chorda tympani nerves in humans

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12 December 2020

Epithelial overexpression of BDNF or NT4 disrupts targeting of taste neurons that innervate the anterior tongue

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12 December 2020

Shh and Ptc are associated with taste bud maintenance in the adult mouse

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12 December 2020

Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition

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12 December 2020

Time course of morphological alterations of fungiform papillae and taste buds following chorda tympani transection in neonatal rats.

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12 December 2020

Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila

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12 December 2020

Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium

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12 December 2020

Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae

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12 December 2020

Taste buds on the cat's circumvallate papilla after reinnervation by glossopharyngeal, vagus, and hypoglossal nerves

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12 December 2020

A strong nerve dependence of sonic hedgehog expression in basal cells in mouse taste bud and an autonomous transcriptional control of genes in differentiated taste cells

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12 December 2020

Sonic hedgehog exerts distinct, stage-specific effects on tongue and taste papilla development

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12 December 2020

Taste disturbance and its recovery after middle ear surgery

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12 December 2020

Shh signaling and regulatory gene expression in mouse taste buds

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12 December 2020

Chorda tympani nerve transection at different developmental ages produces differential effects on taste bud volume and papillae morphology in the rat

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12 December 2020

Effects of glossopharyngeal nerve section on the expression of neurotrophins and their receptors in lingual taste buds of adult mice

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12 December 2020

Epithelial overexpression of BDNF and NT4 produces distinct gustatory axon morphologies that disrupt initial targeting

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12 December 2020

Bone morphogenetic proteins and noggin: inhibiting and inducing fungiform taste papilla development

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12 December 2020

Wnt-beta-catenin signaling initiates taste papilla development

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12 December 2020

Wnt signaling interacts with Shh to regulate taste papilla development

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12 December 2020

Development of fungiform papillae: patterned lingual gustatory organs

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12 December 2020

Cell lineage and differentiation in taste buds

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12 December 2020

Fungiform taste bud degeneration in C57BL/6J mice following chorda-lingual nerve transection

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12 December 2020

Salivary secretion, taste and hyposalivation

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12 December 2020

Stem cells and niches: mechanisms that promote stem cell maintenance throughout life

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12 December 2020

Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K/Akt, MEK/ERK, and p38 MAPK signaling

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12 December 2020

Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palate

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12 December 2020

Fate mapping of mammalian embryonic taste bud progenitors

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12 December 2020

Sonic hedgehog mediates BDNF-induced neuroprotection against mitochondrial inhibitor 3-nitropropionic acid.

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12 December 2020

WNT5a in tongue and fungiform Papilla development

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12 December 2020

Chorda tympani nerve analysis with electron microscopy in chronic suppurative otitis media

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12 December 2020

Stem cells and the niche: a dynamic duo.

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12 December 2020

Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain-derived neurotrophic factor against mitochondrial inhibition

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12 December 2020

Sonic Hedgehog Protects Cortical Neurons Against Oxidative Stress

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12 December 2020

Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells

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12 December 2020

FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size.

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12 December 2020

Length of nerve gap defects correlates with incidence of nerve regeneration but not with recovery of taste function in patients with severed chorda tympani nerve.

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12 December 2020

Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development

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12 December 2020

A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle.

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12 December 2020

Hyposalivation after undergoing stapedectomy

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12 December 2020

Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori

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12 December 2020

Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome

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12 December 2020

Taste damage (otitis media, tonsillectomy and head and neck cancer), oral sensations and BMI

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12 December 2020

Sonic Hedgehog regulates brain-derived neurotrophic factor in normal and regenerating cavernous nerves.

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12 December 2020

Protracted delay in taste sensation recovery after surgical lingual nerve repair: a case report

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12 December 2020

The mechanisms of Hedgehog signalling and its roles in development and disease

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12 December 2020

Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance

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12 December 2020

Taste bud homeostasis in health, disease, and aging

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12 December 2020

Observation of regenerated fungiform taste buds after severing the chorda tympani nerve using confocal laser scanning microscopy in vivo.

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12 December 2020

Traversing the basement membrane in vivo: a diversity of strategies

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12 December 2020

Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor

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12 December 2020

Sonic hedgehog-expressing basal cells are general post-mitotic precursors of functional taste receptor cells

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12 December 2020

Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium.

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12 December 2020

Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds

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12 December 2020

Hedgehog pathway blockade with the cancer drug LDE225 disrupts taste organs and taste sensation

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12 December 2020

Developing and regenerating a sense of taste

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12 December 2020

Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.

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12 December 2020

Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium

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12 December 2020

Taste perception, associated hormonal modulation, and nutrient intake

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12 December 2020

Evidence-based outcomes following inferior alveolar and lingual nerve injury and repair: a systematic review.

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12 December 2020

Shrinkage of ipsilateral taste buds and hyperplasia of contralateral taste buds following chorda tympani nerve transection

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12 December 2020

Sonic Hedgehog Promotes Neurite Outgrowth of Primary Cortical Neurons Through Up-Regulating BDNF Expression.

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12 December 2020

Progress and renewal in gustation: new insights into taste bud development

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12 December 2020

Long-term Follow-up Results of Regeneration Process of Fungiform Taste Buds After Severing the Chorda Tympani Nerve During Middle Ear Surgery

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12 December 2020

Taste Bud-Derived BDNF Is Required to Maintain Normal Amounts of Innervation to Adult Taste Buds

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12 December 2020

Hedgehog Pathway Inhibitor Therapy for Locally Advanced and Metastatic Basal Cell Carcinoma: A Systematic Review and Pooled Analysis of Interventional Studies

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12 December 2020

Oral sensory nerve damage: Causes and consequences

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12 December 2020

Managing adverse events associated with vismodegib in the treatment of basal cell carcinoma

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12 December 2020

Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling.

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12 December 2020

Sonic hedgehog is present in parotid saliva and is decreased in patients with taste dysfunction.

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12 December 2020

Tongue and Taste Organ Biology and Function: Homeostasis Maintained by Hedgehog Signaling

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12 December 2020

More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy.

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12 December 2020

Profiling intraoral neuropathic disturbances following lingual nerve injury and in burning mouth syndrome

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12 December 2020

BDNF is required for taste axon regeneration following unilateral chorda tympani nerve section

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12 December 2020

Change of somatosensory function of the tongue caused by chorda tympani nerve disorder after stapes surgery.

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12 December 2020

Taste bud-derived BDNF maintains innervation of a subset of TrkB-expressing gustatory nerve fibers.

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12 December 2020

Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid.

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12 December 2020

Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance.

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12 December 2020

Feasibility of preservation of chorda tympani nerve during noninflammatory ear surgery: A systematic review.

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12 December 2020

Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib

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12 December 2020

Neuronal delivery of Hedgehog directs spatial patterning of taste organ regeneration

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12 December 2020

Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification

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12 December 2020

Gli3 is a negative regulator of Tas1r3-expressing taste cells.

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12 December 2020

The Sonic Hedgehog signaling pathway regulates inferior alveolar nerve regeneration

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12 December 2020

Taste Changes in Patients With Middle Ear Surgery by Intraoperative Manipulation of Chorda Tympani Nerve

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12 December 2020

The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease.

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12 December 2020

Sonic hedgehog signaling in spinal cord contributes to morphine-induced hyperalgesia and tolerance through upregulating brain-derived neurotrophic factor expression.

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12 December 2020

Post-tonsillectomy taste dysfunction: Myth or reality?

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12 December 2020

Signaling in the stem cell niche: regulating cell fate, function and plasticity

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12 December 2020

Species generalization and differences in Hedgehog pathway regulation of fungiform and circumvallate papilla taste function and somatosensation demonstrated with sonidegib

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12 December 2020