Phase 1 trial of linifanib (ABT-869) in patients with refractory or relapsed acute myeloid leukemia. (Q53389797)

13 May 2018

title

Phase 1 trial of linifanib (ABT-869) in patients with refractory or relapsed acute myeloid leukemia. (English)

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13 May 2018

main subject

phase I clinical trial

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author name string

Eunice S Wang

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13 May 2018

Karen Yee

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13 May 2018

Liang Piu Koh

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Donna Hogge

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13 May 2018

Sari Enschede

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Dawn M Carlson

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13 May 2018

Matthew Dudley

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Keith Glaser

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Evelyn McKeegan

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Daniel H Albert

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Xiaohui Li

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Rajendra Pradhan

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Wendy Stock

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13 May 2018

publication date

1 March 2012

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13 May 2018

published in

Leukemia & Lymphoma

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volume

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issue

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page(s)

1543-1551

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Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

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Sequential continuous infusion of fludarabine and cytarabine associated with liposomal daunorubicin (DaunoXome) (FLAD) in primary refractory or relapsed adult acute myeloid leukemia patients

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Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: a comparative analysis of 120 paired diagnostic and relapse bone marrow samples

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ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside

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Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

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Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation

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A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy

21 January 2018

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ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia

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Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor

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Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway

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Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

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Phase I and biomarker study of ABT-869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies

21 January 2018

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Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors

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Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia

21 January 2018

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A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: a NCIC (National Cancer Institute of Canada) Clinical Trials Group Study

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Phase I study of sorafenib in patients with refractory or relapsed acute leukemias

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Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3

21 January 2018

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Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse

21 January 2018

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A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias

21 January 2018

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A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response

21 January 2018

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10.3109/10428194.2012.660631

21 January 2018

Identifiers

DOI

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13 May 2018

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13 May 2018