PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS. (Q50980480)

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21 March 2020

title

PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS (English)

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21 March 2020

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21 March 2020

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21 March 2020

Gilberto S Almeida

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21 March 2020

Martin Galler

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21 March 2020

Ian Wilson

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21 March 2020

Huw D Thomas

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21 March 2020

Suzanne Kyle

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21 March 2020

David R Newell

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21 March 2020

Ross J Maxwell

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publication date

22 May 2017

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21 March 2020

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volume

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issue

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Poly (ADP-ribose) polymerase (PARP): rationale, preclinical and clinical evidences of its inhibition as breast cancer treatment

21 March 2020

cites work

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Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity

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Intracellular redox state revealed by in vivo (31) P MRS measurement of NAD(+) and NADH contents in brains

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Vasoactivity of AG014699, a clinically active small molecule inhibitor of poly(ADP-ribose) polymerase: a contributory factor to chemopotentiation in vivo?

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Alkylating DNA damage stimulates a regulated form of necrotic cell death

21 January 2018

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Tumour cell retention of rucaparib, sustained PARP inhibition and efficacy of weekly as well as daily schedules

21 January 2018

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

21 January 2018

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Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors.

21 January 2018

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21 January 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.

21 January 2018

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An analysis of DNA repair as a determinant of survival in patients with non-small-cell lung cancer.

21 January 2018

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Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

21 January 2018

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Serum nicotinamide adenine dinucleotide levels through disease course in multiple sclerosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/NBM.3736

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21 March 2020

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