Modulation of Bax and mTOR for Cancer Therapeutics. (Q50662513)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

title

Modulation of Bax and mTOR for Cancer Therapeutics (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Rui Li

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Chunyong Ding

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Jun Zhang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Maohua Xie

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Dongkyoo Park

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Ye Ding

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Guo Chen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Guojing Zhang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Melissa Gilbert-Ross

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Wei Zhou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Adam I Marcus

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Shi-Yong Sun

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Zhuo G Chen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Gabriel L Sica

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Suresh S Ramalingam

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Haian Fu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Fadlo R Khuri

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Walter J Curran

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Taofeek K Owonikoko

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Dong M Shin

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Jia Zhou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

Xingming Deng

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

language of work or name

English

0 references

publication date

5 April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

page(s)

3001-3012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy

16 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

A Translational, Pharmacodynamic, and Pharmacokinetic Phase IB Clinical Study of Everolimus in Resectable Non-Small Cell Lung Cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Small-molecule Bax agonists for cancer therapy

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Patient-derived xenograft models: an emerging platform for translational cancer research

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Phase II study of everolimus-erlotinib in previously treated patients with advanced non-small-cell lung cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Novel small-molecule inhibitors of Bcl-XL to treat lung cancer.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Phase II study of docetaxel in combination with everolimus for second- or third-line therapy of advanced non-small-cell lung cancer.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Rapamycin induces Bad phosphorylation in association with its resistance to human lung cancer cells

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

The dual PI3K/mTOR inhibitor BEZ235 is effective in lung cancer cell lines.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Phase II study of everolimus (RAD001) in previously treated small cell lung cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Mono- or double-site phosphorylation distinctly regulates the proapoptotic function of Bax

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

The PI3-K/AKT-pathway and radiation resistance mechanisms in non-small cell lung cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Maximizing mouse cancer models

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

LKB1 modulates lung cancer differentiation and metastasis

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Rationale for a phase I trial of erlotinib and the mammalian target of rapamycin inhibitor everolimus (RAD001) for patients with relapsed non small cell lung cancer

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Bcl2's flexible loop domain regulates p53 binding and survival

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Nicotine inactivation of the proapoptotic function of Bax through phosphorylation.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Development of a high-throughput fluorescence polarization assay for Bcl-x(L)

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Novel role for JNK as a stress-activated Bcl2 kinase

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Structure of Bax: coregulation of dimer formation and intracellular localization

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Conformation of the Bax C-terminus regulates subcellular location and cell death

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

18 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5503158

Development of three human small cell lung cancer models in nude mice

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28381544

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-16-2356

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

release_7fhnl3slvvbuzpiimrirseqlgq

16 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7fhnl3slvvbuzpiimrirseqlgq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

PubMed publication ID

28381544

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28381544%20AND%20SRC:MED&resulttype=core&format=json