Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids (Q50456117)

14 March 2018

title

Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids (English)

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14 March 2018

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Julian Stevenson

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14 March 2018

Winnie Luu

series ordinal

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14 March 2018

Ika Kristiana

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14 March 2018

Andrew J Brown

series ordinal

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14 March 2018

language of work or name

English

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publication date

1 August 2014

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14 March 2018

published in

Biochemical Journal

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14 March 2018

volume

461

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14 March 2018

issue

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14 March 2018

page(s)

435-442

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14 March 2018

Protein sensors for membrane sterols

cites work

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Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis

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Synthesis and antifungal activity of a series of N-substituted [2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)]propylamines

21 January 2018

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Squalene epoxidase as hypocholesterolemic drug target revisited

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Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase

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SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase

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A feed-forward loop amplifies nutritional regulation of PNPLA3

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Fat-specific protein 27 undergoes ubiquitin-dependent degradation regulated by triacylglycerol synthesis and lipid droplet formation

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Post-translational regulation of perilipin expression. Stabilization by stored intracellular neutral lipids

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Degradation of perilipin is mediated through ubiquitination-proteasome pathway

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Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step

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Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis

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Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C delta pathway

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The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.

21 January 2018

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Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

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Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells.

21 January 2018

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Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum

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Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA

21 January 2018

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Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic

21 January 2018

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Association of stomatin with lipid bodies

21 January 2018

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DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes

21 January 2018

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Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila

21 January 2018

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21 January 2018

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Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

21 January 2018

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Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BJ20131404

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14 March 2018

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14 March 2018