Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system (Q45007196)

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English	Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system	scientific article

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scholarly article

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8 December 2017

Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system (English)

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8 December 2017

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author name string

Oleg S Gorbatyuk

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Margaret J Velardo

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Carmen S Peden

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8 December 2017

Philip Williams

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8 December 2017

Sergei Zolotukhin

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Paul J Reier

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8 December 2017

Ronald J Mandel

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8 December 2017

Nicholas Muzyczka

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publication date

1 August 2004

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Molecular Therapy

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10

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2

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8 December 2017

302-317

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8 December 2017

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

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Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector

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Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

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Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors

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Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

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Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease

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Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.

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Regulation of gene expression in vivo following transduction by two separate rAAV vectors

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Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease

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7 January 2021

Adeno-associated virus-mediated gene transfer to the brain: duration and modulation of expression

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Uniform long-term gene expression using adeno-associated virus (AAV) by ex vivo recirculation in rat-cardiac isografts

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Development of hammerhead ribozymes to modulate endogenous gene expression for functional studies.

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Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion

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Use of adeno-associated viral vector for delivery of small interfering RNA.

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Optic neuropathy induced by reductions in mitochondrial superoxide dismutase

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Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study

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Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults

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Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice

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Gene transfer into the mouse retina mediated by an adeno-associated viral vector

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Efficient transduction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters

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7 January 2021

Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors

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7 January 2021

Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system

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7 January 2021

Selective and rapid uptake of adeno-associated virus type 2 in brain

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7 January 2021

Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

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7 January 2021

Selective gene expression in brain microglia mediated via adeno-associated virus type 2 and type 5 vectors

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Convection-enhanced delivery of AAV-2 combined with heparin increases TK gene transfer in the rat brain.

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7 January 2021

Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain: quantitative analysis of heparin co-infusion

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7 January 2021

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer

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Targeted retrograde gene delivery for neuronal protection

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Distribution of a lysosomal enzyme in the adult brain by axonal transport and by cells of the rostral migratory stream.

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Intraventricular brain injection of adeno-associated virus type 1 (AAV1) in neonatal mice results in complementary patterns of neuronal transduction to AAV2 and total long-term correction of storage lesions in the brains of beta-glucuronidase-defici

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Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

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Adeno-associated viruses undergo substantial evolution in primates during natural infections

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Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors

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Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors

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Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model

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Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size.

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Recombinant AAV serotype 1 transduction efficiency and tropism in the murine brain

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Adeno-associated virus vector-mediated transduction in the cat brain

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CMV-beta-actin promoter directs higher expression from an adeno-associated viral vector in the liver than the cytomegalovirus or elongation factor 1 alpha promoter and results in therapeutic levels of human factor X in mice

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Neonatal intramuscular injection with recombinant adeno-associated virus results in prolonged beta-glucuronidase expression in situ and correction of liver pathology in mucopolysaccharidosis type VII mice.

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Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

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7 January 2021

Recombinant AAV-mediated gene delivery to the central nervous system.

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Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

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Recombinant adeno-associated virus vector: use for transgene expression and anterograde tract tracing in the CNS

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Tropism of AAV-2 vectors for neurons of the globus pallidus

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Recombinant adeno-associated viral vector-mediated glial cell line-derived neurotrophic factor gene transfer protects nigral dopamine neurons after onset of progressive degeneration in a rat model of Parkinson's disease

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Gene transfer and expression in oligodendrocytes under the control of myelin basic protein transcriptional control region mediated by adeno-associated virus

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Adeno-associated virus vectors: activity and applications in the CNS.

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Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer

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Adenovirus-facilitated nuclear translocation of adeno-associated virus type 2.

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Rate limiting steps of AAV transduction and implications for human gene therapy.

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Endocytosis of adeno-associated virus type 5 leads to accumulation of virus particles in the Golgi compartment

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Developmental expression of platelet-derived growth factor alpha-receptor in neurons and glial cells of the mouse CNS.

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Novel tools for production and purification of recombinant adenoassociated virus vectors

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Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors

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Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

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Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism

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A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells

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Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector

1 reference

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based on heuristic

inferred from DOI database lookup

Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.05.024

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.YMTHE.2004.05.024

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 December 2017

ResearchGate publication ID

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