Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction (Q38938450)

7 September 2017

title

Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction (English)

1 reference

7 September 2017

author

David A Taylor-Fishwick

1 reference

7 September 2017

Dieter Schmoll

0 references

Ajit Jadhav

0 references

Anton Simeonov

1 reference

7 September 2017

Jessica Weaver

1 reference

7 September 2017

Lindsey Glenn

1 reference

7 September 2017

Norine Kuhn

1 reference

7 September 2017

Ganesha Rai

1 reference

7 September 2017

Angela Dudda

1 reference

7 September 2017

Theodore R Holman

1 reference

7 September 2017

David J Maloney

1 reference

7 September 2017

Jerry L Nadler

1 reference

7 September 2017

language of work or name

1 reference

23 November 2014

1 reference

7 September 2017

1 reference

7 September 2017

1 reference

7 September 2017

1 reference

7 September 2017

page(s)

549-557

1 reference

Targeting inflammation in the treatment of type 2 diabetes: time to start

7 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

The pancreatic β cell and type 1 diabetes: innocent bystander or active participant?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Increased number of islet-associated macrophages in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Functional and pathological roles of the 12- and 15-lipoxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Production and function of IL-12 in islets and beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

A practical guide to rodent islet isolation and assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Regulation of NOX-1 expression in beta cells: a positive feedback loop involving the Src-kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3452-0

Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet

21 January 2018

1 reference

12 December 2020

Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes?

1 reference

12 December 2020

Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism

1 reference

12 December 2020

Inflammation, stress, and diabetes

1 reference

12 December 2020

Selective expression of an arachidonate 12-lipoxygenase by pancreatic islet beta-cells

1 reference

12 December 2020

Body condition scoring: a rapid and accurate method for assessing health status in mice

1 reference

12 December 2020

10.1007/S00125-014-3452-0

Identifiers

DOI

1 reference

Dimensions Publication ID

7 September 2017

1017673399

0 references

1 reference