Novel oncoprotein EPS8: a new target for anticancer therapy (Q38150879)

29 August 2017

title

Novel oncoprotein EPS8: a new target for anticancer therapy (English)

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29 August 2017

Yu-Hua Li

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29 August 2017

Tong-Yuan Xue

series ordinal

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29 August 2017

Ying-Zhi He

series ordinal

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29 August 2017

Jing-Wen Du

series ordinal

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29 August 2017

language of work or name

English

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publication date

1 October 2013

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29 August 2017

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29 August 2017

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29 August 2017

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29 August 2017

page(s)

1587-1594

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Overexpression of p97Eps8 leads to cellular transformation: implication of pleckstrin homology domain in p97Eps8-mediated ERK activation

29 August 2017

cites work

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Eps8 decreases chemosensitivity and affects survival of cervical cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Eps8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Expression of Eps8 correlates with poor survival in oral squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Gene expression in papillary thyroid carcinoma reveals highly consistent profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Epidermal growth factor receptor pathway substrate 8 is overexpressed in human pituitary tumors: role in proliferation and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

PTB domain-directed substrate targeting in a tyrosine kinase from the unicellular choanoflagellate Monosiga brevicollis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Eps8 in the midst of GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Effect of pH and salt bridges on structural assembly: Molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

EPS8 and E3B1 transduce signals from Ras to Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Identification of EPS8 as a Dvl1-associated molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

A novel peptide-SH3 interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Epidermal growth factor receptor: mechanisms of activation and signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Eps8 controls actin-based motility by capping the barbed ends of actin filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

EPS8 upregulates FOXM1 expression, enhancing cell growth and motility

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: implications for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

FoxM1 is required for execution of the mitotic programme and chromosome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Role for EPS8 in squamous carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Participation of p97Eps8 in Src-mediated transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Enhancement of tyrosyl phosphorylation and protein expression of eps8 by v-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Focal adhesion kinase: the first ten years

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

The gelsolin family of actin regulatory proteins: modular structures, versatile functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Defining actin filament length in striated muscle: rulers and caps or dynamic stability?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Cell migration: Rho GTPases lead the way

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

c-Jun N-terminal kinase 2 (JNK2) enhances cell migration through epidermal growth factor substrate 8 (EPS8).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

The signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Down-regulation of CXCL5 inhibits squamous carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

The regulatory role of the juxtamembrane region in the activity of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

Application and potential limitations of animal models utilized in the development of trastuzumab (Herceptin): a case study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.104

21 January 2018

Identifiers

DOI

10.2217/FON.13.104

1 reference

29 August 2017

1 reference