From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses (Q38135197)

29 August 2017

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22 October 2022

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses (English)

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Middle East respiratory syndrome

29 August 2017

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Rolf Hilgenfeld

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29 August 2017

Malik Peiris

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29 August 2017

publication date

6 September 2013

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29 August 2017

1 October 2013

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22 October 2022

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29 August 2017

22 October 2022

100

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29 August 2017

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29 August 2017

page(s)

286-295

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Structural insights into SARS coronavirus proteins

29 August 2017

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Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

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The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease

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A multicentre collaboration to investigate the cause of severe acute respiratory syndrome.

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The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world.

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Crystal structure of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein dimerization domain reveals evolutionary linkage between corona- and arteriviridae

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Structural basis for coronavirus-mediated membrane fusion. Crystal structure of mouse hepatitis virus spike protein fusion core

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Crystal Structures of Two Coronavirus ADP-Ribose-1''-Monophosphatases and Their Complexes with ADP-Ribose: a Systematic Structural Analysis of the Viral ADRP Domain

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Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.

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12 December 2020

Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China

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12 December 2020

Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains

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12 December 2020

Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family

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12 December 2020

Structure of Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Has Implications for Coronavirus nsp1 Function and Evolution

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12 December 2020

Structure of a proteolytically resistant core from the severe acute respiratory syndrome coronavirus S2 fusion protein

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12 December 2020

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

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12 December 2020

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques

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12 December 2020

Structure of the X (ADRP) domain of nsp3 from feline coronavirus

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12 December 2020

Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

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12 December 2020

The 29-nucleotide deletion present in human but not in animal severe acute respiratory syndrome coronaviruses disrupts the functional expression of open reading frame 8.

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12 December 2020

SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum

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12 December 2020

Antiapoptotic Activity by HIV Protease Inhibitors either Alone or Boostered

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12 December 2020

Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme

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12 December 2020

Virus-host interactomes--antiviral drug discovery

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12 December 2020

Nuclear Magnetic Resonance Structure of the Nucleic Acid-Binding Domain of Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein 3

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12 December 2020

Treatment of SARS with human interferons

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12 December 2020

Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer

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12 December 2020

Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10.

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12 December 2020

Small molecules targeting severe acute respiratory syndrome human coronavirus

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12 December 2020

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

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12 December 2020

Nuclear Magnetic Resonance Structure Shows that the Severe Acute Respiratory Syndrome Coronavirus-Unique Domain Contains a Macrodomain Fold

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12 December 2020

Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein

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12 December 2020

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12 December 2020

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12 December 2020

The molecular biology of coronaviruses

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12 December 2020

Structural proteomics of the SARS coronavirus: a model response to emerging infectious diseases

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12 December 2020

The Effects of Temperature and Relative Humidity on the Viability of the SARS Coronavirus.

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12 December 2020

The nsp9 replicase protein of SARS-coronavirus, structure and functional insights

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12 December 2020

Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures

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12 December 2020

Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property

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12 December 2020

Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein

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12 December 2020

Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China

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12 December 2020

Epidemiologic clues to SARS origin in China

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12 December 2020

Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A.

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12 December 2020

Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3.

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12 December 2020

Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor

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12 December 2020

New antiviral target revealed by the hexameric structure of mouse hepatitis virus nonstructural protein nsp15.

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12 December 2020

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

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12 December 2020

Structure of the C-terminal domain of nsp4 from feline coronavirus

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12 December 2020

The nucleocapsid protein of coronavirus infectious bronchitis virus: crystal structure of its N-terminal domain and multimerization properties

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12 December 2020

X-Ray Structures of the N- and C-Terminal Domains of a Coronavirus Nucleocapsid Protein: Implications for Nucleocapsid Formation

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12 December 2020

The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.

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12 December 2020

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

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12 December 2020

Ribonucleocapsid Formation of Severe Acute Respiratory Syndrome Coronavirus through Molecular Action of the N-Terminal Domain of N Protein

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12 December 2020

Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe

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12 December 2020

Structure of the SARS coronavirus nucleocapsid protein RNA-binding dimerization domain suggests a mechanism for helical packaging of viral RNA

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12 December 2020

Cyclosporin A inhibits the replication of diverse coronaviruses

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12 December 2020

Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution

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12 December 2020

Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors

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12 December 2020

Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs

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12 December 2020

Expression cloning of functional receptor used by SARS coronavirus

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12 December 2020

Nidovirus transcription: how to make sense...?

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12 December 2020

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

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12 December 2020

Novel β-Barrel Fold in the Nuclear Magnetic Resonance Structure of the Replicase Nonstructural Protein 1 from the Severe Acute Respiratory Syndrome Coronavirus

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12 December 2020

Coronaviruses post-SARS: update on replication and pathogenesis

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12 December 2020

Ribavirin and interferon-beta synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines.

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12 December 2020

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

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12 December 2020

Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R.

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12 December 2020

Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin

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12 December 2020

Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters

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12 December 2020

Solution structure of the c-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method

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12 December 2020

Crystal Structure of the C-Terminal Cytoplasmic Domain of Non-Structural Protein 4 from Mouse Hepatitis Virus A59

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12 December 2020

Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats

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12 December 2020

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

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12 December 2020

Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein.

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12 December 2020

Laboratory diagnosis of four recent sporadic cases of community-acquired SARS, Guangdong Province, China

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12 December 2020

pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses

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12 December 2020

Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain of human coronavirus OC43 nucleocapsid protein

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12 December 2020

Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

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12 December 2020

Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates

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12 December 2020

Emerging respiratory viruses: challenges and vaccine strategies

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12 December 2020

Identification of a new human coronavirus

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12 December 2020

Hospital outbreak of Middle East respiratory syndrome coronavirus

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12 December 2020

Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia

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12 December 2020

Design of wide-spectrum inhibitors targeting coronavirus main proteases

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12 December 2020

A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting

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12 December 2020

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus

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12 December 2020

Structures of Two Coronavirus Main Proteases: Implications for Substrate Binding and Antiviral Drug Design

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12 December 2020

A contemporary view of coronavirus transcription.

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12 December 2020

Characterization of a novel coronavirus associated with severe acute respiratory syndrome

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12 December 2020

Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein Complex

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12 December 2020

The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors

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12 December 2020

Core structure of S2 from the human coronavirus NL63 spike glycoprotein

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12 December 2020

Nuclear Magnetic Resonance Structure of the N-Terminal Domain of Nonstructural Protein 3 from the Severe Acute Respiratory Syndrome Coronavirus

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12 December 2020

First cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human transmission, France, May 2013.

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12 December 2020

Coronavirus N Protein N-Terminal Domain (NTD) Specifically Binds the Transcriptional Regulatory Sequence (TRS) and Melts TRS-cTRS RNA Duplexes

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12 December 2020

Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques

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12 December 2020

The structure of a rigorously conserved RNA element within the SARS virus genome

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12 December 2020

Solution structure of the severe acute respiratory syndrome-coronavirus heptad repeat 2 domain in the prefusion state

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12 December 2020

The Genome sequence of the SARS-associated coronavirus

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12 December 2020

NMR Structure of the SARS-CoV Nonstructural Protein 7 in Solution at pH 6.5

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12 December 2020

Coronavirus as a possible cause of severe acute respiratory syndrome

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12 December 2020

Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies

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12 December 2020

Solution Structure of Mouse Hepatitis Virus (MHV) nsp3a and Determinants of the Interaction with MHV Nucleocapsid (N) Protein

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12 December 2020

The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes

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12 December 2020

Bats are natural reservoirs of SARS-like coronaviruses

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12 December 2020

Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013.

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12 December 2020

Variable oligomerization modes in coronavirus non-structural protein 9

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12 December 2020

10.1016/J.ANTIVIRAL.2013.08.015

Identifiers

DOI

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29 August 2017

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