Current status and perspectives on protein-based pneumococcal vaccines (Q38124921)

29 August 2017

title

Current status and perspectives on protein-based pneumococcal vaccines (English)

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29 August 2017

Luciana Cezar de Cerqueira Leite

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29 August 2017

Michelle Darrieux

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29 August 2017

Cibelly Goulart

series ordinal

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29 August 2017

David Briles

series ordinal

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29 August 2017

language of work or name

English

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publication date

29 July 2013

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Critical Reviews in Microbiology

29 August 2017

published in

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29 August 2017

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29 August 2017

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29 August 2017

page(s)

190-200

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Identification and characterization of a novel family of pneumococcal proteins that are protective against sepsis

29 August 2017

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A pneumococcal pilus influences virulence and host inflammatory responses

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21 January 2018

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Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae

21 January 2018

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The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae

21 January 2018

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A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence

21 January 2018

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Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection

21 January 2018

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Mucosal immunization with purified ClpP could elicit protective efficacy against pneumococcal pneumonia and sepsis in mice

21 January 2018

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Protective activity of Streptococcus pneumoniae Spr1875 protein fragments identified using a phage displayed genomic library

21 January 2018

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Immunization with DnaJ (hsp40) could elicit protection against nasopharyngeal colonization and invasive infection caused by different strains of Streptococcus pneumoniae

21 January 2018

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The proline-rich region of pneumococcal surface proteins A and C contains surface-accessible epitopes common to all pneumococci and elicits antibody-mediated protection against sepsis

21 January 2018

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Fusion proteins containing family 1 and family 2 PspA fragments elicit protection against Streptococcus pneumoniae that correlates with antibody-mediated enhancement of complement deposition.

21 January 2018

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PspC, a pneumococcal surface protein, binds human factor H.

21 January 2018

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Dual roles of PspC, a surface protein of Streptococcus pneumoniae, in binding human secretory IgA and factor H.

21 January 2018

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The Streptococcus pneumoniae pilus-1 displays a biphasic expression pattern

21 January 2018

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A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae

21 January 2018

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Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases

21 January 2018

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DNA vaccines based on genetically detoxified derivatives of pneumolysin fail to protect mice against challenge with Streptococcus pneumoniae

21 January 2018

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https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface protein PspA and PspC nasal vaccines against a respiratory pneumococcal challenge in mice

21 January 2018

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https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Streptococcus pneumoniae pilus subunits protect mice against lethal challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Sortase A confers protection against Streptococcus pneumoniae in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

The pneumococcal eukaryotic-type serine/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies

21 January 2018

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https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Preclinical Evaluation of the Pht Proteins as Potential Cross-Protective Pneumococcal Vaccine Antigens

21 January 2018

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https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Immunization with a ZmpB-based protein vaccine could protect against pneumococcal diseases in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Relationship between surface accessibility for PpmA, PsaA, and PspA and antibody-mediated immunity to systemic infection by Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Characterization of protective immune responses induced by pneumococcal surface protein A in fusion with pneumolysin derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Selection of family 1 PspA molecules capable of inducing broad-ranging cross-reactivity by complement deposition and opsonophagocytosis by murine peritoneal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

PppA, a surface-exposed protein of Streptococcus pneumoniae, elicits cross-reactive antibodies that reduce colonization in a murine intranasal immunization and challenge model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Prevention of pneumococcal disease in mice immunized with conserved surface-accessible proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

RrgB321, a fusion protein of the three variants of the pneumococcal pilus backbone RrgB, is protective in vivo and elicits opsonic antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Molecular architecture of Streptococcus pneumoniae TIGR4 pili

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Diversity of PspA: mosaic genes and evidence for past recombination in Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Antibodies to pneumococcal proteins PhtD, CbpA, and LytC in Filipino pregnant women and their infants in relation to pneumococcal carriage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Genome of the Bacterium Streptococcus pneumoniae Strain R6

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Allelic variation in the highly polymorphic locus pspC of Streptococcus pneumoniae.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Mn2+-dependent regulation of multiple genes in Streptococcus pneumoniae through PsaR and the resultant impact on virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Safety and immunogenicity of the pneumococcal pneumolysin derivative PlyD1 in a single-antigen protein vaccine candidate in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Immunogenicity and protective efficacy of DnaJ (hsp40) of Streptococcus pneumoniae against lethal infection in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Vaccine candidates PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

PcpA of Streptococcus pneumoniae mediates adherence to nasopharyngeal and lung epithelial cells and elicits functional antibodies in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Construction and immunological characterization of a novel nontoxic protective pneumolysin mutant for use in future pneumococcal vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Protective humoral response against pneumococcal infection in mice elicited by recombinant bacille Calmette-Guérin vaccines expressing pneumococcal surface protein A.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Evaluation of new generation Salmonella enterica serovar Typhimurium vaccines with regulated delayed attenuation to induce immune responses against PspA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Glycolytic enzymes associated with the cell surface of Streptococcus pneumoniae are antigenic in humans and elicit protective immune responses in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Immunization with native or recombinant Streptococcus pneumoniae neuraminidase affords protection in the chinchilla otitis media model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Protection against Pneumococcal colonization and fatal pneumonia by a trivalent conjugate of a fusion protein with the cell wall polysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Pneumolysin: a double-edged sword during the host-pathogen interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Molecular analysis of the psa permease complex of Streptococcus pneumoniae.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

The immune response to pneumococcal proteins during experimental human carriage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Nasal immunization with Lactococcus lactis expressing the pneumococcal protective protein A induces protective immunity in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Development of cross-reactive antibodies to the proline-rich region of pneumococcal surface protein A in children

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Localization of PcsB of Streptococcus pneumoniae and its differential expression in response to stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Next generation pneumococcal vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Immunization of mice with single PspA fragments induces antibodies capable of mediating complement deposition on different pneumococcal strains and cross-protection.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Streptococcus pneumoniae: proteomics of surface proteins for vaccine development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Pneumococcal surface protein A inhibits complement deposition on the pneumococcal surface by competing with the binding of C-reactive protein to cell-surface phosphocholine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Intranasal immunization with recombinant PspA fused with a flagellin enhances cross-protective immunity against Streptococcus pneumoniae infection in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Vaccine-induced human antibodies to PspA augment complement C3 deposition on Streptococcus pneumoniae.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Identification of genes that contribute to the pathogenesis of invasive pneumococcal disease by in vivo transcriptomic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Protection against Streptococcus pneumoniae elicited by immunization with pneumolysin and CbpA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Novel protein-based pneumococcal vaccines administered with the Th1-promoting adjuvant IC31 induce protective immunity against pneumococcal disease in neonatal mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Induction of systemic and mucosal immune response and decrease in Streptococcus pneumoniae colonization by nasal inoculation of mice with recombinant lactic acid bacteria expressing pneumococcal surface antigen A.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Combination of pneumococcal surface protein A (PspA) with whole cell pertussis vaccine increases protection against pneumococcal challenge in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Differential protein expression in phenotypic variants of Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

The role of Streptococcus pneumoniae sortase A in colonisation and pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

The contribution of pneumolysin to the pathogenicity of Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen A fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

The absence of PspA or presence of antibody to PspA facilitates the complement-dependent phagocytosis of pneumococci in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Transcriptional regulation, occurrence and putative role of the Pht family of Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Regions of PspA/EF3296 best able to elicit protection against Streptococcus pneumoniae in a murine infection model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Neutralizing antibodies elicited by a novel detoxified pneumolysin derivative, PlyD1, provide protection against both pneumococcal infection and lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Immunogenicity and tolerability of a multicomponent meningococcal serogroup B (4CMenB) vaccine in healthy adolescents in Chile: a phase 2b/3 randomised, observer-blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Characterization of a novel leucine-rich repeat protein antigen from group B streptococci that elicits protective immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Safety and immunogenicity of a pneumococcal histidine triad protein D vaccine candidate in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Role of polyamine transport in Streptococcus pneumoniae response to physiological stress and murine septicemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Immunization with polyamine transport protein PotD protects mice against systemic infection with Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

PspA protects Streptococcus pneumoniae from killing by apolactoferrin, and antibody to PspA enhances killing of pneumococci by apolactoferrin [corrected].

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Immunogenicity of a live recombinant Salmonella enterica serovar typhimurium vaccine expressing pspA in neonates and infant mice born from naive and immunized mothers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Supramolecular Organization of the Repetitive Backbone Unit of the Streptococcus pneumoniae Pilus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Protection of mice against fatal pneumococcal challenge by immunization with pneumococcal surface adhesin A (PsaA).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Immunization with recombinant Streptococcus pneumoniae neuraminidase NanA protects chinchillas against nasopharyngeal colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Virulence of Streptococcus pneumoniae: PsaA mutants are hypersensitive to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Administration of a probiotic associated with nasal vaccination with inactivated Lactococcus lactis-PppA induces effective protection against pneumoccocal infection in young mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Immune responses to recombinant pneumococcal PsaA antigen delivered by a live attenuated Salmonella vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Serotype replacement in disease after pneumococcal vaccination

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

The pneumococcus: why a commensal misbehaves

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Concomitant administration of recombinant PsaA and PCV7 reduces Streptococcus pneumoniae serotype 19A colonization in a murine model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Human nasal challenge with Streptococcus pneumoniae is immunising in the absence of carriage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Immunization with a combination of three pneumococcal proteins confers additive and broad protection against Streptococcus pneumoniae Infections in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Intranasal immunization with autolysin (LytA) in mice model induced protection against five prevalent Streptococcus pneumoniae serotypes in China

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Recombinant PhpA protein, a unique histidine motif-containing protein from Streptococcus pneumoniae, protects mice against intranasal pneumococcal challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Protection induced by pneumococcal surface protein A (PspA) is enhanced by conjugation to a Streptococcus pneumoniae capsular polysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

Humoral immune response of a pneumococcal conjugate vaccine: Capsular polysaccharide serotype 14—Lysine modified PspA

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1040841X.2013.813902

10.3109/1040841X.2013.813902

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference