p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. (Q36443527)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16601753%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

review article

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title

p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress (English)

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19 January 2020

1 reference

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19 January 2020

Jean-Christophe Bourdon

series ordinal

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19 January 2020

F Murray-Zmijewski

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19 January 2020

publication date

1 June 2006

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Cell Death & Differentiation

19 January 2020

published in

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19 January 2020

volume

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19 January 2020

issue

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19 January 2020

page(s)

962-972

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T antigen is bound to a host protein in SY40-transformed cells

19 January 2020

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p63 and the epithelial stem cell: more than status quo?

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Differential recognition of response elements determines target gene specificity for p53 and p63

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Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes.

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TP53 family members and human cancers

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p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes

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p63 is the molecular switch for initiation of an epithelial stratification program

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p63: oncogene or tumor suppressor?

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p63 deficiency activates a program of cellular senescence and leads to accelerated aging

21 January 2018

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Histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: a study of 250 cases

21 January 2018

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The transactivating isoforms of p63 are overexpressed in high-grade follicular lymphomas independent of the occurrence of p63 gene amplification.

21 January 2018

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Differential expression of p63 isoforms in normal tissues and neoplastic cells

21 January 2018

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p63 is a p53 homologue required for limb and epidermal morphogenesis

21 January 2018

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Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

21 January 2018

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p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation.

21 January 2018

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Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63

21 January 2018

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Functional regulation of p73 and p63: development and cancer

21 January 2018

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DeltaNp73beta is active in transactivation and growth suppression.

21 January 2018

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An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

21 January 2018

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Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression

21 January 2018

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Two new p73 splice variants, gamma and delta, with different transcriptional activity.

21 January 2018

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p63 and p73 transactivate differentiation gene promoters in human keratinocytes

21 January 2018

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

21 January 2018

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Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53.

21 January 2018

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Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo

21 January 2018

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Alternative splicing of the p53 tumor suppressor gene in the Molt-4 T-lymphoblastic leukemia cell line

21 January 2018

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Regulation of human p53 activity and cell localization by alternative splicing

21 January 2018

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Identification of a novel p53 functional domain that is necessary for mediating apoptosis

21 January 2018

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p53: link to the past, bridge to the future

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A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint

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Drosophila p53 binds a damage response element at the reaper locus

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

21 January 2018

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Refined solution structure of the oligomerization domain of the tumour suppressor p53

21 January 2018

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Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.

21 January 2018

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Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

21 January 2018

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

21 January 2018

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Further characterisation of the p53 responsive element--identification of new candidate genes for trans-activation by p53

21 January 2018

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7 January 2021

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

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7 January 2021

Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63

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7 January 2021

Enhanced p73 expression during differentiation and complex p73 isoforms in myeloid leukemia

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7 January 2021

Expression of DeltaNp73 is a molecular marker for adverse outcome in neuroblastoma patients

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7 January 2021

p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products

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7 January 2021

p53-dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53

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7 January 2021

Wild-type alternatively spliced p53: binding to DNA and interaction with the major p53 protein in vitro and in cells.

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7 January 2021

A subset of p53-deficient embryos exhibit exencephaly

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7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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7 January 2021