siRNA-based approaches in cancer therapy (Q36373107)

13 August 2017

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title

siRNA-based approaches in cancer therapy (English)

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13 August 2017

Devi GR

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13 August 2017

publication date

20 January 2006

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13 August 2017

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13 August 2017

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13 August 2017

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13 August 2017

page(s)

819-829

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13 August 2017

cites work

Cancer statistics, 2005

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Anti-genes: siRNA, ribozymes and antisense

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Synthetic hammerhead ribozymes as therapeutic tools to control disease genes

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Triplex DNA structures.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Searching genomes for sequences with the potential to form intrastrand triple helices.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Peptide nucleic acids: versatile tools for gene therapy strategies

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Targeting double stranded DNA with peptide nucleic acid (PNA).

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Novel antisense and peptide nucleic acid strategies for controlling gene expression

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

In Vivo Modulation of N-myc Expression by Continuous Perfusion with an Antisense Oligonucleotide

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Antisense oligonucleotides: promise and reality.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Progress in antisense technology.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Inhibition of coagulation by a phosphorothioate oligonucleotide.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Bolus intravenous injection of phosphorothioate oligonucleotides causes hypotension by acting as alpha(1)-adrenergic receptor antagonists

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Reaction between metabolically activated acetaminophen and phosphorothioate oligonucleotides

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Evidence of enhanced iron excretion during systemic phosphorothioate oligodeoxynucleotide treatment

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Antisense technologies. Improvement through novel chemical modifications

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Morpholino antisense oligomers: design, preparation, and properties

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Resistance of morpholino phosphorodiamidate oligomers to enzymatic degradation

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Effect of TNF-alpha antisense oligomers on cytokine production by primary murine alveolar macrophages.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Effective targeted gene 'knockdown' in zebrafish

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

In vivo evaluation of a morpholino antisense oligomer directed against tumor necrosis factor-alpha

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Local delivery of c-myc neutrally charged antisense oligonucleotides with transport catheter inhibits myointimal hyperplasia and positively affects vascular remodeling in the rabbit balloon injury model.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

c-myc antisense oligonucleotide treatment ameliorates murine ARPKD.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Antiproliferative effects of steric blocking phosphorodiamidate morpholino antisense agents directed against c-myc

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Resistance to chemotherapeutic drugs overcome by c-Myc inhibition in a Lewis lung carcinoma murine model

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

In vivo bioavailability and pharmacokinetics of a c-MYC antisense phosphorodiamidate morpholino oligomer, AVI-4126, in solid tumors

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Arginine-rich cell-penetrating peptides with uncharged antisense oligomers

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Post-transcriptional gene silencing across kingdoms

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

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7 January 2021

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Small RNAs correspond to centromere heterochromatic repeats

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

RNAi extends its reach

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Induction and suppression of RNA silencing: insights from viral infections

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Perspective: machines for RNAi

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

The ins and outs of RNAi in mammalian cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Expression profiling reveals off-target gene regulation by RNAi

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Noise amidst the silence: off-target effects of siRNAs?

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

The developmental role of microRNA in plants

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

siRNA and miRNA: an insight into RISCs

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Transcription and processing of human microRNA precursors

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Unlocking the potential of the human genome with RNA interference

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

RNA interference targeting Fas protects mice from fulminant hepatitis

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

In vivo transfer and expression of genes coding for short interfering RNAs.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Stable suppression of tumorigenicity by virus-mediated RNA interference

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Retroviruses as tools to study the immune system

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Lentiviral-mediated RNA interference

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Local gene knockdown in the brain using viral-mediated RNA interference.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Adenoviral vectors expressing siRNAs for discovery and validation of gene function

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Utilization of adenovirus vectors for multiple gene transfer applications

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Gene silencing by adenovirus-delivered siRNA.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Specific gene inhibition by adenovirus-mediated expression of small interfering RNA

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Progress and problems with the use of viral vectors for gene therapy

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Transduction of multiple cell types using improved conditions for gene delivery and expression of SV40 pseudovirions packaged in vitro.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

RNA interference in adult mice.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Gene silencing by systemic delivery of synthetic siRNAs in adult mice

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

RNA interference in mammalian cells by chemically-modified RNA.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

A resource for large-scale RNA-interference-based screens in mammals.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Molecular determinants for the tissue specificity of SERMs

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

High-throughput gene silencing using cell arrays.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

A system for stable expression of short interfering RNAs in mammalian cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Effective expression of small interfering RNA in human cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Oncology studies using siRNA libraries: the dawn of RNAi-based genomics

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

siRNA agents inhibit oncogene expression and attenuate human tumor cell growth

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Induction of apoptosis in HeLa cells with siRNA expression vector targeted against bcl-2

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Matrix Metalloproteinase-9 Silencing by RNA Interference Triggers the Migratory-adhesive Switch in Ewing's Sarcoma Cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi).

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Suppression of Epstein-Barr virus-encoded latent membrane protein-1 by RNA interference inhibits the metastatic potential of nasopharyngeal carcinoma cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571).

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi).

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Role of Toll-like receptors in antisense and siRNA [corrected].

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Activation of the interferon system by short-interfering RNAs

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA.

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700931

7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700931

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13 August 2017

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