Histone-deacetylase inhibitors: novel drugs for the treatment of cancer (Q34743301)

4 August 2017

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title

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer (English)

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4 August 2017

Ricky W Johnstone

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language of work or name

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1 April 2002

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

287-299

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4 August 2017

cites work

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Translating the Histone Code

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Histone acetyltransferases: function, structure, and catalysis

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Acetylation of histones and transcription-related factors

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The human histone deacetylase family

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Functional significance of histone deacetylase diversity

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The emerging role of class II histone deacetylases

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Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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Negative control of p53 by Sir2alpha promotes cell survival under stress

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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DNA methylation, methyltransferases, and cancer

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Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

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Histone acetylases and deacetylases in cell proliferation

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Chromatin remodeling in development and differentiation.

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Conjunction dysfunction: CBP/p300 in human disease.

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Mutations truncating the EP300 acetylase in human cancers

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p300/CBP/p53 interaction and regulation of the p53 response

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Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)

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Transcriptional regulation in acute promyelocytic leukemia.

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Translocations of the RARalpha gene in acute promyelocytic leukemia

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Transcription therapy for cancer

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Mechanisms of transcriptional repression by the t(8;21)-, t(12;21)-, and inv(16)-encoded fusion proteins

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AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.

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Control of muscle development by dueling HATs and HDACs

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

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Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

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DNA methylation, chromatin inheritance, and cancer

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Sequence-specific DNA recognition by polyamides

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Activation of gene expression by small molecule transcription factors

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Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A.

31 March 2020

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

31 March 2020

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Histone deacetylase inhibitors as new cancer drugs

31 March 2020

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Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

31 March 2020

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

31 March 2020

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Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

31 March 2020

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

31 March 2020

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Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

31 March 2020

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Histone deacetylases and cancer: causes and therapies

31 March 2020

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Histone deacetylase as a therapeutic target

31 March 2020

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Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells.

31 March 2020

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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

31 March 2020

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The retinoblastoma gene family in differentiation and development.

31 March 2020

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P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

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Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

31 March 2020

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Coordinating cell proliferation and differentiation

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The ins and outs of nucleosome assembly

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Apoptotic pathways: paper wraps stone blunts scissors

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Cancer cell sensitization to fas-mediated apoptosis by sodium butyrate

31 March 2020

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Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts

31 March 2020

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Fungal metabolite FR901228 inhibits c-Myc and Fas ligand expression

31 March 2020

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Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphoblasts.

31 March 2020

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Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines.

31 March 2020

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Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma

31 March 2020

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Sequential 5-Aza-2 deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1.

31 March 2020

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Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17).

31 March 2020

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Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction

31 March 2020

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Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors

31 March 2020

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Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells

31 March 2020

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Inhibition of histone deacetylation induces constitutive derepression of the beta interferon promoter and confers antiviral activity

31 March 2020

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Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

31 March 2020

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Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin

31 March 2020

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Histone deacetylase: a target for antiproliferative and antiprotozoal agents

31 March 2020

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Inhibitors of histone deacetylase as new anticancer agents

31 March 2020

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Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates

31 March 2020

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A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

31 March 2020

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Dysregulation of apoptosis in cancer

31 March 2020

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Telomerase activation by histone deacetylase inhibitor in normal cells

31 March 2020

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Histone deacetylases, transcriptional control, and cancer

31 March 2020

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Sodium butyrate induces growth arrest and senescence-like phenotypes in gynecologic cancer cells

31 March 2020

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FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice

31 March 2020

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A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

31 March 2020

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In vivo effects of a histone deacetylase inhibitor, FK228, on human acute promyelocytic leukemia in NOD / Shi-scid/scid mice.

31 March 2020

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Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase.

31 March 2020

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Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

31 March 2020

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Histone deacetylase inhibitors promote apoptosis and differential cell cycle arrest in anaplastic thyroid cancer cells

31 March 2020

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Chromatin remodeling and Rb activity

31 March 2020

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Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis.

31 March 2020

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In vivo complex formation of PU.1 with HDAC1 associated with PU.1-mediated transcriptional repression

31 March 2020

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The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression

31 March 2020

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Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

31 March 2020

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Duration of nuclear NF-kappaB action regulated by reversible acetylation

31 March 2020

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DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

31 March 2020

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BRCA1 interacts with components of the histone deacetylase complex

31 March 2020

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Histone deacetylase 1 can repress transcription by binding to Sp1.

31 March 2020

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MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

31 March 2020

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The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1.

31 March 2020

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DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

31 March 2020

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Deacetylation of p53 modulates its effect on cell growth and apoptosis

31 March 2020

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Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD772

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Dimensions Publication ID

4 August 2017

1014646894

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